特发性视网膜前膜的发病机制  

Pathogenesis of idiopathic epiretinal membrane

作　　者：杨挺宇 解来青[1] 徐国旭[1] Yang Tingyu;Xie Laiqing;Xu Guoxu(Department of Ophthalmology,the Second Affiliated Hospital of Soochow University,Suzhou 215004,China)

机构地区：[1]苏州大学附属第二医院眼科,215004

出　　处：《国际眼科纵览》2022年第5期448-453,共6页International Review of Ophthalmology

摘　　要：视网膜前膜分为特发性和继发性。特发性视网膜前膜的发生不与其他任何眼部疾病相关,其完整的发病机制目前尚未明了,但已有许多理论被提出,如玻璃体后脱离、纤维化机制、神经退行性变、表观遗传修饰等。异常的纤维化导致细胞外基质(extracellular matrix,ECM)合成、沉积和降解三因素失衡,大量ECM沉积,是特发性视网膜前膜发病的重要环节。对特发性视网膜前膜实验模型的研制有助于深入探索其发病机制及指导临床治疗。Epiretinal membrane(ERM)can be divided into idiopathic epiretinal membrane(iERM)and secondary epiretinal membrane(sERM).The occurrence of iERM is not associated with any other ocular diseases.The complete pathogenesis of iERM is still unclear,but many theories have been proposed,including posterior vitreous detachment(PVD),fibrosis,neurodegeneration and epigenetic modification.Abnormal fibrosis leads to an unbalance of the extracellular matrix(ECM)synthesis,deposition and degradation.An important part of iERM is massive ECM deposition.The experimental models about iERM will develop the exploration of pathogenesis of iERM deeply and guide clinical treatment.

关 键 词：特发性视网膜前膜/发病机制 

分 类 号：R774.1[医药卫生—眼科]