短程强化门诊心理干预对双相障碍患者服药依从性的影响  

The impact of Intensive outpatient program on medication compliance in patients with bipolar disorder

作　　者：张洁[1] 丁菲 孙霞 王勇[1] 卢卫红 薛莉莉 黄佳[1] 吴志国 吴丹萍 叶尘宇[6] 王宇[7] 宋蕊[7] 方贻儒 苑成梅[1] ZHANG Jie;DING Fei;SUN Xia;WANG Yong;LU Wei-hong;XUE Li-li;HUANG Jia;WU Zhi-guo;WU Dan-ping;YE Chen-yu;WANG Yu;SONG Rui;FANG Yi-ru;YUAN Cheng-mei(Department of Psychosomatic medicine,Shanghai Mental Health Center,Shanghai Jiao Tong Unitersity School of Medicine,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心,200030 [2]杭州市第七人民医院 [3]上海交通大学医学院附属仁济医院 [4]上海市杨浦区精神卫生中心 [5]上海交通大学医学院附属新华医院 [6]复旦大学附属中山医院 [7]上海市虹口区精神卫生中心 [8]中国科学院上海生命科学院神经科学研究所(中科院脑智卓越中心),上海市重性精神病重点实验室

出　　处：《临床精神医学杂志》2023年第1期1-5,共5页Journal of Clinical Psychiatry

基　　金：上海市申康发展中心重大临床研究项目-青年项目(SHDC2020CR4074);上海市科委科技创新行动计划(20Y11906600);上海市精神卫生中心睡眠障碍特色学科(2017-TSXK-02);心身医学(2019ZB0201);上海市申康发展中心“适宜技术联合开发推广应用”项目(SHDC12016205);上海市精神心理疾病临床医学研究中心项目(19MC1911100);上海市卫健委上海市中医药事业发展三年行动计划(2018~2020年)治未病服务重点推广项目(ZY(2018-2020)-ZWB-1001-FWB-07)。

摘　　要：目的:探讨短程强化门诊心理干预项目(intensive outpatient program,IOP)对新近缓解(近4个月有1次急性发作,目前处于缓解期)双相障碍患者服药依从性的影响。方法:将双相障碍患者按本人意愿分为研究组49例(常规药物治疗合并IOP)和对照组26例(常规药物治疗)。使用药物依从性评价量表(MARS)分别在干预前、干预结束时和干预结束3个月末评估患者服药依从性。结果:两组患者在干预前、干预结束时及干预结束3个月末MARS总分比较显示,研究组较对照组在干预结束后MARS总分提高,差异有统计学意义(P<0.05),而在干预前、干预结束后3个月差异均无统计学意义(P>0.05)。干预结束时及干预结束3个月末,研究组患者MARS总分持续上升,而对照组MARS总分在干预结束时下降,在干预结束3个月末上升。结论:IOP干预对新近缓解双相障碍患者的服药依从性有改善,促进疾病康复。Objective:To explore the impact of Intensive Outpatient Program(IOP)on the medication compliance of patients with bipolar disorder who had one acute mood episode within 4 months but got remission now.Method:26 patients were distributed into control group(treat as usual,TAU),49 patients were signed into study group(TAU plus IOP)according to their preference.Medication Adherence Rating Scale(MARS)were used to assess the medication compliance of patients with bipolar disorder at baseline,the intervention end and 3 months after the intervention.Results:The MARS scores of the two groups were compared before the intervention,at the end of the intervention study and 3 months after the intervention.The total MARS score of the study group was improved after the intervention(P<0.05)compared to control group.The total MARS score of the two group groups had no statistical difference at baseline and 3 months after the intervention(P>0.05).The total MARS score of the study group was rising through the intervention end and 3 months after the intervention.MARS score of the control group was going down the intervention end and going up 3 months after the intervention.Conclusion:IOP can improve medication compliance and promote rehabilitation for patients with biopolar disorder who got remission recently.

关 键 词：双相障碍 服药依从性 强化门诊心理干预 

分 类 号：R749.4[医药卫生—神经病学与精神病学]