受体-供体-受体结构光疗试剂用于近红外二区荧光成像和光声成像引导的光动力和光热联合治疗  

Acceptor-donor-acceptor structured phototheranostics for near-infraredⅡfluorescent and photoacoustic imaging-guided photodynamic and photothermal synergistic therapy

作　　者：李宝伶 甘亚兵 杨柯 庞娥 任晓杰 赵少静 何旦 赵富稳 王本花 尹鹏 宋相志 蓝敏焕 Baoling Li;Yabing Gan;Ke Yang;E Pang;Xiaojie Ren;Shaojing Zhao;Dan He;Fuwen Zhao;Benhua Wang;Peng Yin;Xiangzhi Song;Minhuan Lan(Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety,College of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China;State Key Laboratory of Powder Metallurgy,Central South University,Changsha 410083,China;Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education),Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province,Hunan Normal University,Changsha 410083,China;Department of Chemistry and Center of Super-Diamond and Advanced Films(COSDAF),City University of Hong Kong,China)

机构地区：[1]Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety,College of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China [2]State Key Laboratory of Powder Metallurgy,Central South University,Changsha 410083,China [3]Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education),Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province,Hunan Normal University,Changsha 410083,China [4]Department of Chemistry and Center of Super-Diamond and Advanced Films(COSDAF),City University of Hong Kong,China

出　　处：《Science China Materials》2023年第1期385-394,共10页中国科学（材料科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(62175262);the Fundamental Research Funds for the Central Universities(2020CX021);the Key R&D plan of Hunan Province(2022SK2101)。

摘　　要：多模态成像引导的光动力和光热治疗在癌症治疗上具有明显的优势.同时具有近红外光(NIR)吸收、高活性氧(ROS)产率和高光热转换效率的物质是非常理想的光疗试剂.本文设计合成了一种具有“受体-供体-受体”(A-D-A)结构的分子IDCIC.随后通过在IDCIC表面包裹DSPE-PEG2000-NH2得到了水溶性纳米颗粒IDCIC NPs.IDCIC NPs具有近红外吸收,峰值位于760 nm;同时还具有近红外二区荧光发射,峰值在1000 nm左右,荧光量子产率为1.2%,使得IDCIC NPs具有良好的光声成像和NIR-Ⅱ荧光成像能力.此外,IDCIC NPs在808 nm激光器照射下可以同时产生单线态氧(量子产率为9.1%)、羟基自由基(·OH)和热量(光热转换效率为78.9%).基于以上这些特性,IDCIC NPs可以用于多模态成像引导的光动力/光热联合癌症治疗.Multi-modal imaging-guided synergistic photodynamic therapy(PDT)and photothermal therapy(PTT)show great benefits in cancer treatment.The phototheranostics with near-infrared(NIR)absorption,high reactive oxygen species(ROS)generation and photothermal conversion efficiency is highly desirable.Here,we designed and synthesized an“acceptor-donor-acceptor”(A-D-A)structured molecule named IDCIC,with strong absorbance in the NIR region.We further prepared IDCIC into watersoluble nanoparticles(NPs)by wrapping with 1,2-distearoylsn-glycero-3-phosphoethanolamine-N-[(polyethylene glycol)-2000]-amine(DSPE-PEG2000-NH2).The obtained IDCIC NPs show an NIR absorption peak at 760 nm and an NIR-Ⅱfluorescence spectrum peak at~1000 nm with a fluorescent quantum yield of 1.2%,enabling them excellent photoacoustic and NIR-Ⅱfluorescent imaging capabilities.Moreover,IDCIC NPs could simultaneously generate singlet oxygen(with a quantum yield of 9.1%),hydroxyl radicals(·OH)and heat(with a photothermal conversion efficiency of 78.9%)under 808-nm laser irradiation.Based on the above-mentioned properties,IDCIC NPs were used for dual-modal imagingguided synergistic photodynamic/photothermal therapy of cancer.

关 键 词：光动力 癌症治疗 光热治疗 光声成像 荧光成像 光疗 近红外吸收 受体结构 

分 类 号：R730.4[医药卫生—肿瘤]