VEGF及VEGF受体-2基因多态性与阿尔茨海默病患者脑微出血的相关性研究  

Relationship Study on the VEGF and VEGFR Gene Polymorphism and Cerebral Microbleeds in Alzheimer’s Disease

作　　者：张金彪[1] 孙海荣[1] 李梦凡[1] 沈腾群 王彤[1] 赵俊武[1] 李芳 李振光[1] ZHANG Jinbiao;SUN Hairong;LI Mengfan(Department of Neurology,Weihai Municipal Hospital,Weihai City,Shandong Province 264200;不详)

机构地区：[1]威海市立医院神经内科,山东省威海市264200 [2]锦州医科大学附属第一医院神经内科

出　　处：《医学理论与实践》2023年第4期544-548,543,共6页The Journal of Medical Theory and Practice

基　　金：山东省自然科学基金面上项目(ZR2017MH011)。

摘　　要：目的:探讨血管内皮生长因子(VEGF)或VEGF受体-2(VEGFR2)基因的单核苷酸多态性(SNPs)是否与阿尔茨海默病(AD)中脑微出血(CMBs)风险增加相关。方法:对406例AD患者和332例非AD患者进行了基因分型,包括VEGF-116G> A,-460T>C,405G>C,+936C>T,VEGFR2-604T>C,-1719T>A,Val297Ile SNPs。采用多因素Logistic回归分析评估AD患者伴或不伴CMBs的VEGF及VEGFR2基因变异之间的关系。结果:对比伴和不伴CMBs的AD患者,VEGF-116G>A,-460T>C,405G>C,+936C>T SNPs的基因频率无显著差异。在校正了年龄、性别、脑血管危险因素和携带至少一个APOEε4等位基因后,在VEGF受体-2基因中,变异型-1719T>A与AD易感性增加相关,与野生型基因型相比,变异型297Ile与AD和CMBs的易感性增加相关。结论:VEGFR2 Val297Ile SNP可能作为中国北方汉族人群AD或CMBs风险增加的遗传标记。Objective:To evaluated whether single nucleotide polymorphisms(SNPs) of VEGF or VEGF receptor-2 genes are associated with an increased risk of CMBs in Alzheimer’s disease(AD).Methods:A total of 406 patients with AD and 332 controls were genotyped for the VEGF-116G>A,-460T>C,405G>C,+936C>T,and VEGFR2-604T>C,-1719T>A, Val297Ile SNPs.Multiple Logistic regression analysis was executed to evaluate the association between variants in VEGF and VEGF receptor-2 genes in AD patients with and without CMBs. Results:Genotype frequencies for VEGF-116G>A,-460T>C,405G>C,+936C>T SNPs did not differ significantly between AD patients with and without CMBs. In the VEGF receptor-2 gene, the variant-1719T>A was associated with increased susceptibility to AD,the variant 297Ile was associated with increased susceptibility to AD and CMBs in AD patients compared with the wild-type genotype after adjustment for age, gender, cerebrovascular risk factors, and carrying at least one copy of the APOEε4 allele. Conclusion:The VEGFR2 Val297Ile SNP may serve as a genetic marker for the increased risk of AD or CMBs in AD patients among the Northern Chinese Han population.

关 键 词：阿尔茨海默病 VEGF VEGF受体-2 遗传多态性 脑微出血 

分 类 号：R749.16[医药卫生—神经病学与精神病学]