依达拉奉右莰醇与阿托伐他汀对老年急性脑梗死伴颅内动脉狭窄患者脂代谢及炎症影响  

Effects of edaravone dexborneol plus atorvastatin on lipid metabolism and inflammation in elderly patients with ACI combined with IAS

作　　者：李卫征 武国良 吴强 Li Weizheng;Wu Guoliang;Wu Qiang(Department of Neurology,Xinxiang Central Hospital Forth Clinical College of Xinxiang Medical University,Xinxiang 453000,Henan Province,China)

机构地区：[1]新乡市中心医院(新乡医学院第四临床学院)神经内科,453000

出　　处：《中华老年心脑血管病杂志》2023年第1期57-61,共5页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨依达拉奉右莰醇+阿托伐他汀治疗老年急性脑梗死伴颅内动脉狭窄患者的效果及对脂代谢和炎症的影响。方法选取2020年3月至2021年4月新乡市中心医院神经内科收治的老年急性脑梗死伴颅内动脉狭窄患者90例,采取随机数字表法分为2组,每组45例。对照组给予阿托伐他汀治疗,观察组给予阿托伐他汀联合依达拉奉右莰醇治疗。采用血栓弹力图监测凝血启动-血块形成潜伏期(R值)、从R时间终点到幅度达20 mm需要时间(K值)、凝固至最大振幅时间(M值)、血块最大强度(Ma值)、从血块形成点至最大曲线弧度做切线,与水平线的夹角(α角),对比2组疗效。结果观察组治疗后1周、2周美国国立卫生研究院卒中量表评分较对照组明显降低(P<0.01)。观察组总有效率明显高于对照组(93.3%vs 68.9%,P<0.01)。观察组治疗后TC、TG、LDL-C、M值、Ma值、α角、白细胞介素(IL)-2、IL-6、IL-8、低切黏度、高切黏度、红细胞比容、血浆比黏度及椎动脉、颈内动脉、基底动脉、大脑中动脉血液流速明显低于对照组,HDL-C、R值、K值明显高于对照组,差异有统计学意义(P<0.05,P<0.01)。2组均随访6~13(9.51±1.28)个月。观察组再狭窄率明显低于对照组(0%vs 13.3%,P=0.035),2组无死亡病例。结论依达拉奉右莰醇+阿托伐他汀治疗老年急性脑梗死伴颅内动脉狭窄的疗效确切,预后良好。Objective To investigate the efficacy of edaravone dexborneol in combination with atorvastatin in treatment of elderly patients with acute cerebral infarction complicated with intracranial artery stenosis and their effects on lipid metabolism and inflammation.Methods A total of 90 elderly patients with acute cerebral infarction complicated with intracranial artery stenosis admitted to our department from March 2020 to April 2021 were recruited and randomly divided into control group and observation group,with 45 cases in each group.The control group was treated with atorvastatin,and the observation group was treated with atorvastatin combined with edaravone dexborneol.Thrombelastography was used to monitor the time of latency from clot initiation and clot formation(R value),the time from the end of R time to the amplitude of 20 mm(K value),the time from coagulation to the maximum amplitude(M value),the maximum clot strength(Ma value),the tangent line from the clot formation to the maximum curve radian,and the angle between the horizontal line(αangle).The efficacy of the 2 groups was compared.Results The scores of National Institutes of Health Stroke Scale at 1 and 2 weeks after treatment were significantly lower in the observation group than the control group(P<0.01).The former group obtained obviously higher total effective rate than the control group(93.3%vs 68.9%,P<0.01).After treatment,the levels of TC,TG,LDL-C,IL-2,IL-6 and IL-8,M value,Ma value,αangle,low shear viscosity,high shear viscosity,red blood cell volume,plasma specific viscosity and blood flow velocities in the vertebral artery,internal carotid artery,basilar artery and middle cerebral artery were remarkably lower,while the HDL-C level,R value and K value were notably higher in the observation group than the control group(P<0.05,P<0.01).Both groups were followed up for 6 to 13(9.51±1.28)months.The restenosis rate in the observation group was significantly lower than that in the control group(0%vs 13.3%,P=0.035).No case of death was observed in

关 键 词：依达拉奉 右莰醇 阿托伐他汀 脑梗死 颅内动脉疾病 动脉粥样硬化 血栓弹力描记术 

分 类 号：R743.33[医药卫生—神经病学与精神病学]