康复新液辅助治疗小儿口腔溃疡疗效观察及对免疫功能的影响  

Curative Effect Observation of Kangfuxin Liquid in Adjuvant Therapy of Oral Ulcer in Children and Its Effect on Immune Function

作　　者：许紫薇 XU Ziwei

机构地区：[1]金华市人民医院口腔科,浙江金华321000

出　　处：《新中医》2022年第24期133-137,共5页New Chinese Medicine

摘　　要：目的:观察康复新液辅助治疗小儿口腔溃疡的临床疗效及其对免疫功能的影响。方法:选取105例口腔溃疡患儿作回顾性分析,根据治疗方法的不同将其分为对照组53例和观察组52例。对照组给予口腔炎喷雾剂及复合维生素B片治疗;观察组在对照组的基础上加用康复新液口服。比较2组临床疗效、症状改善时间、不良反应、复发情况,以及治疗前后中医证候评分、溃疡面积、充血程度、疼痛视觉模拟评分法(VAS)评分、免疫功能变化。结果:观察组总有效率为92.30%、复发率为2.08%,对照组分别为83.01%、13.64%,2组比较,差异均有统计学意义(P<0.05)。治疗前,2组口臭、口内疼痛、口渴、尿黄便秘、舌红苔黄等中医证候评分比较,差异无统计学意义(P>0.05);治疗后,2组上述各项评分均较治疗前降低(P<0.05),且观察组各项评分均低于对照组(P<0.05)。治疗后,观察组溃疡疼痛缓解时间、溃疡愈合时间、食欲改善时间均短于对照组,差异有统计学意义(P<0.05)。治疗前,2组溃疡面积、充血程度、VAS评分比较,差异无统计学意义(P>0.05);治疗后,2组上述各项指标均较治疗前降低(P<0.05),且观察组各项指标均低于对照组(P<0.05)。治疗前,2组血清CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平比较,差异无统计学意义(P>0.05);治疗后,2组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均较治疗前上升(P<0.05),CD8^(+)较治疗前下降(P<0.05),且观察组上述各项指标改善较对照组更显著(P<0.05)。观察组不良反应发生率为5.76%,对照组为18.86%,2组比较,差异有统计学意义(P<0.05)。结论:康复新液辅助治疗小儿口腔溃疡可提高疗效,降低不良反应发生率,有效改善患儿临床症状,提高免疫功能,且安全性较高。Objective:To observe the clinical effect of Kangfuxin Liquid in adjuvant therapy of oral ulcer in children and its effect on immune function. Methods:A total of 105 cases of children with oral ulcer were selected for retrospective analysis and divided into the control group and the observation group according to different treatment methods, with 53 and 52 cases in each group respectively. The control group was treated with routine treatment, sprays for stomatitis, and compound vitamin B tablets. The observation group was additionally treated with the oral administration with Kangfuxin Liquid based on the treatment of the control group. Clinical effects,the time of symptom improvement,adverse reactions and recurrence were compared between the two groups. The changes in traditional Chinese medicine(TCM) syndrome scores,ulcer area,congestion degree,scores of Visual Analog Score(VAS) for pain and immune function before and after treatment were compared between the two groups. Results:In the observation group,the total effective rate was 92.30% and the recurrence rate was 2.08%;in the control group,the total effective rate was 83.01% and the recurrence rate was 13.64%, differences being significant(P<0.05).Before treatment, there was no significant difference being found in the comparison of TCM syndrome scores of bad breath,pain in mouth,thirst,yellow-coloured urine and costipation,and red tongue and yellow coating between the two groups(P>0.05). After treatment,each TCM syndrome score in the two groups was decreased(P<0.05),and the score in the observation group was lower than that in the control group(P<0.05). After treatment, the remission time of ulcer pain, the healing time of ulcer, and the improvement time of appetite in the observation group were shorter than those in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of ulcer area,congestion degree and VAS scores between the two groups(P>0.05);after treatment, the abo

关 键 词：口腔溃疡 儿童 康复新液 复合维生素B 免疫功能 

分 类 号：R781.5[医药卫生—口腔医学]