Quorum sensing-based interactions among drugs,microbes,and diseases  

作　　者：Shengbo Wu Shujuan Yang Manman Wang Nan Song Jie Feng Hao Wu Aidong Yang Chunjiang Liu Yanni Li Fei Guo Jianjun Qiao 

机构地区：[1]School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China [2]School of Computer Science and Engineering,Central South University,Changsha 410083,China [3]State Key Laboratory of Chemical Engineering,Tianjin University,Tianjin 300072,China [4]Collaborative Innovation Center of Chemical Science and Engineering(Tianjin),Tianjin 300072,China [5]Key Laboratory of Systems Bioengineering,Ministry of Education(Tianjin University),Tianjin 300072,China [6]School of Computer Science and Technology,College of Intelligence and Computing,Tianjin University,Tianjin 300350,China [7]Department of Engineering Science,University of Oxford,Oxford OX13PJ,UK [8]Institute of Shaoxing,Tianjin University,Shaoxing 312300,China

出　　处：《Science China(Life Sciences)》2023年第1期137-151,共15页中国科学（生命科学英文版）

基　　金：supported by the National Key Research and Development Project of China(2019YFA0905600,2020YFA0907900);the National Natural Science Foundation of China(31570089,31770076,62172296);the Funds for Creative Research Groups of China(21621004);the New Century Outstanding Talent Support Program,Education Ministry of China。

摘　　要：Many diseases and health conditions are closely related to various microbes,which participate in complex interactions with diverse drugs;nonetheless,the detailed targets of such drugs remain to be elucidated.Many existing studies have reported causal associations among drugs,gut microbes,or diseases,calling for a workflow to reveal their intricate interactions.In this study,we developed a systematic workflow comprising three modules to construct a Quorum Sensing-based Drug-Microbe-Disease(QSDMD)database(http://www.qsdmd.lbci.net/),which includes diverse interactions for more than 8,000 drugs,163 microbes,and 42 common diseases.Potential interactions between microbes and more than 8,000 drugs have been systematically studied by targeting microbial QS receptors combined with a docking-based virtual screening technique and in vitro experimental validations.Furthermore,we have constructed a QS-based drug-receptor interaction network,proposed a systematic framework including various drug-receptor-microbe-disease connections,and mapped a paradigmatic circular interaction network based on the QS-DMD,which can provide the underlying QS-based mechanisms for the reported causal associations.The QS-DMD will promote an understanding of personalized medicine and the development of potential therapies for diverse diseases.This work contributes to a paradigm for the construction of a molecule-receptor-microbe-disease interaction network for human health that may form one of the key knowledge maps of precision medicine in the future.

关 键 词：quorum sensing DRUGS microbe-disease association microbe-host interaction gut microbiota personalized medicine 

分 类 号：Q938[生物学—微生物学]