卵巢颗粒细胞瘤内分泌特点分析:附2例病例报告及文献复习  

Endocrine characteristics of granulosa cell tumor of ovary:A case report of 2 cases and literature review

作　　者：秦鹏菲 陈捷[1] 孙艳丽 陆小燕 顾林[1] Qin Pengfei;Chen Jie;Sun Yanli;Lu Xiaoyan;Gu Lin(Department of Gynecology and Endocrinology,Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University(Nanjing Maternal and Child Health Hospital),Nanjing 210004,China;Department of Radiology,Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University(Nanjing Maternal and Child Health Hospital),Nanjing 210004,China)

机构地区：[1]南京医科大学附属妇产医院(南京市妇幼保健院)妇科内分泌科,江苏南京210004 [2]南京医科大学附属妇产医院(南京市妇幼保健院)放射科,江苏南京210004

出　　处：《实用妇科内分泌电子杂志》2022年第21期108-111,共4页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：成人型卵巢颗粒细胞瘤(AGCTs)是一种罕见的起源于卵巢性索间质的肿瘤,临床症状无特异性,且早期表现隐匿、包块小,因此易被延迟诊断。由于AGCTs常伴有内分泌功能紊乱,故患者往往会因“月经不调”就诊。报告例1为育龄期女性出现促黄体生成素(LH)异常升高,例2为围绝经期女性出现LH、抗缪勒管激素(AMH)异常升高。2例患者既往月经周期规律,均无诱因出现月经周期延长,而性激素分泌水平与同年龄段女性激素分泌规律明显不同。2例患者均行手术治疗,经免疫组织化学及分子检测诊断为卵巢颗粒细胞瘤,术后随访均未见明显异常。因此,对于月经周期异常的女性,应结合性激素水平检测和盆腔MRI进一步排查分泌性激素的肿瘤,以期提高AGCTs的早期诊断率。Adult granulosa cell tumors of ovary(AGCTs) are rare tumors originating from the sex cord stroma of the ovary.The clinical symptoms are nonspecific, and the early manifestations are occultic and small, so the diagnosis is easy to be delayed.Because AGCTs are often accompanied by endocrine dysfunction, patients often see a doctor because of "irregular menstruation".Case 1 was an abnormal increase in luteinizing hormone(LH) in women of childbearing age, and case 2 was an abnormal increase in LH and anti-Müllerian hormone(AMH) in perimenopausal women. The two patients had regular menstrual cycles in the past,and there was no incentive for prolonged menstrual cycles, and the sex hormone secretion level was significantly different from that of women in the same age group. After surgical treatment, the two patients were diagnosed as ovarian granulosa cell tumor by immunohistochemical and molecular detection, and no obvious abnormalities were found in the postoperative follow-up. Therefore,for women with abnormal menstrual cycles, sex hormone level detection and pelvic MRI should be combined to further investigate tumors secreting sex hormones, in order to improve the early diagnosis rate of AGCTs.

关 键 词：成人型卵巢颗粒细胞瘤 抗缪勒管激素 促黄体生成素 雌二醇 盆腔核磁共振 

分 类 号：R737.31[医药卫生—肿瘤]