利培酮在难治性分裂情感性精神病中的应用  

Application of Risperidone in Refractory Schizoaffective Psychosis

作　　者：王震 WANG Zhen(Pharmaceutical Department of Jiamusi Psychiatric Welfare Hospital,Jiamusi 154002,Heilongjiang,China)

机构地区：[1]佳木斯精神病人福利院药剂科,黑龙江佳木斯154002

出　　处：《医学信息》2023年第1期144-147,共4页Journal of Medical Information

摘　　要：目的研究利培酮在难治性分裂情感性精神病(SAP)中的应用价值。方法将2020年2月-2021年12月佳木斯精神病人福利院收治的58例难治性SAP患者,按照随机数字表法分为对照组与观察组,对照组(29例)给予碳酸锂治疗,观察组(29例)在对照组基础上加用利培酮治疗,比较两组精神分裂性症状[阳性症状评定量表(SAPS)]、情感性症状[Bech-Rafaelsen躁狂量表(BRMS)、Beck抑郁问卷(BDI)]、血清生化指标[5-羟色胺(5-HT)、多巴胺(DA)、脑源性神经营养因子(BDNF)]、生活质量[健康调查简表(SF-36)]。结果两组治疗后SAPS评分(幻觉、妄想、怪异行为、阳性思维形式障碍)均有下降且观察组低于对照组(P<0.05);两组治疗后BRMS、BDI评分均有下降,且观察组低于对照组(P<0.05);两组治疗后5-HT、DA、BDNF水平均有升高,且观察组高于对照组(P<0.05);两组治疗后SF-36评分均有升高,且观察组高于对照组(P<0.05)。结论将利培酮应用于难治性SAP治疗中,可改善患者精神分裂性症状与情感性症状,调节其神经递质水平,促使生活质量提升。Objective To study the application value of risperidone in refractory schizoaffective psychosis(SAP).Methods A total of 58 patients with refractory SAP admitted to Jiamusi Psychiatric Hospital from February 2020 to December 2021 were divided into control group and observation group according to the random number table method.The control group(29 cases)was treated with lithium carbonate,and the observation group(29 cases)was treated with risperidone on the basis of the control group.The schizophrenia symptoms[Scale for the Assessment of Positive Symptoms(SAPS)],emotional symptoms[Bech-Rafaelsen Mania Scale(BRMS),Beck Depression Inventory(BDI)],serum biochemical indexes[5-hydroxytryptamine(5-HT),dopamine(DA),brain-derived neurotrophic factor(BDNF)]and quality of life[Short Form-36 Health Survey(SF-36)]were compared between the two groups.Results After treatment,the SAPS scores(hallucinations,delusions,bizarre behaviors,positive thinking disorder)of the two groups were decreased,and those in the observation group were lower than those in the control group(P<0.05).After treatment,the BRMS and BDI scores of the two groups decreased,and those in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of 5-HT,DA and BDNF in the two groups increased,and those in the observation group were higher than those in the control group(P<0.05).The SF-36 scores of the two groups increased after treatment,and those in the observation group were higher than those in the control group(P<0.05).Conclusion The application of risperidone in the treatment of refractory SAP can improve the schizophrenic symptoms and emotional symptoms of patients,regulate the level of neurotransmitters,and improve the quality of life.

关 键 词：分裂情感性精神病 利培酮 精神分裂性症状 情感性症状 生活质量 

分 类 号：R749.4[医药卫生—神经病学与精神病学]