早期强化降血压治疗基底节脑出血患者的效果及其对神经功能缺损的影响  

Effect of early intensive antihypertensive therapy on patients with basal ganglia intracerebral hemorrhage and its influence on neurological function deficits

作　　者：杜永强 彭胜林 陈方云 DU Yongqiang;PENG Shenglin;CHEN Fangyun(Department of Neurosurgery,Longgang District Second People′s Hospital,Shenzhen 518116,Guangdong Province,China;Department of Neurosurgery,Longgang District Third People′s Hospital,Shenzhen 518116,Guangdong Province,China)

机构地区：[1]广东省深圳市龙岗区第二人民医院神经外科,深圳市518116 [2]广东省深圳市龙岗区第三人民医院神经外科,深圳市518116

出　　处：《内科》2022年第6期610-613,共4页Internal Medicine

摘　　要：目的探讨早期强化降血压治疗基底节脑出血患者的效果及其对神经功能缺损的影响。方法选取100例基底节脑出血患者并将其随机分为对照组、观察组,每组50例。两组均进行基础治疗,在此基础上对照组行早期缓和降血压治疗,观察组行早期强化降血压治疗,两组均治疗14 d。比较两组治疗前、后美国国立卫生研究院卒中量表(NIHSS)评分、格拉斯哥昏迷量表(GCS)评分、日常生活活动能力量表(ADL)评分、血肿量、水肿量、疼痛视觉模拟量表(VAS)评分、收缩压,以及治疗期间不良反应发生情况。结果治疗前,两组NIHSS评分、GCS评分、ADL评分、血肿量、水肿量、疼痛VAS评分、收缩压差异均无统计学意义(均P>0.05)。观察组治疗14 d后的NIHSS、GCS、ADL评分均优于对照组,治疗24 h时的血肿量、水肿量、疼痛VAS评分、收缩压均少于/低于对照组(均P<0.05)。治疗期间,两组不良反应发生情况差异无统计学意义(P>0.05)。结论对基底节脑出血患者实施早期强化降血压治疗,能尽快降低收缩压,控制水肿量和血肿量,减轻神经功能缺损程度,缓解疼痛感,提高生活自理能力,且安全性高,值得推广。Objective To investigate the effect of early intensive antihypertensive therapy on patients with basal ganglia intracerebral hemorrhage and its influence on neurological function deficits.Methods A total of 100 patients with basal ganglia intracerebral hemorrhage were selected and randomly divided into a control group or an observation group,with 50 cases in each group.Both groups were given basic treatment,based on which the control group was treated with early moderate antihypertensive therapy,while the observation group was treated with early intensive antihypertensive therapy.Both groups were treated for 14 days.The National Institutes of Health Stroke Scale(NIHSS)score,Glasgow Coma Scale(GCS)score,activities of daily living scale(ADL)score,hematoma volume,edema volume,pain Visual Analogue Scale(VAS)score and systolic blood pressure before and after treatment,as well as the occurrence of adverse reactions during treatment were compared between the two groups.Results Before treatment,there was no statistically significant difference in NIHSS score,GCS score,ADL score,hematoma volume,edema volume,pain VAS score or systolic blood pressure between the two groups(all P>0.05).The NIHSS,GCS and ADL scores of the observation group after 14 days of treatment were better than those of the control group,and the hematoma volume,edema volume,pain VAS score and systolic blood pressure after 24 hours of treatment were less or lower than those of the control group(all P<0.05).During treatment,there was no statistically significant difference in the occurrence of adverse reactions between the two groups(P>0.05).Conclusion Early intensive antihypertensive therapy for patients with basal ganglia intracerebral hemorrhage can reduce systolic blood pressure as soon as possible,control the edema and hematoma volumes,reduce the degree of neurological function deficits,relieve pain,and improve self-care ability,with high safety,which is worth promoting.

关 键 词：早期强化降血压 基底节脑出血 神经功能缺损 血肿 水肿 生活自理能力 

分 类 号：R743.34[医药卫生—神经病学与精神病学]