含ω-3多不饱和脂肪酸的肠内免疫营养支持对老年原发性肝癌经导管动脉化疗栓塞术后患者炎性因子水平、能量摄入和肠黏膜屏障功能的影响  

Effects of enteral immune nutrition support containingω-3 polyunsaturated fatty acid on inflammatory factors levels,energy intake,and intestinal mucosal barrier function in elderly primary liver cancer patients after transcatheter arterial chemoemboliz

作　　者：姚水丽 白建玉 杨丹丹 YAO Shuili;BAI Jianyu;YANG Dandan(Interventional Department,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan Province,China;Department of Orthopedics,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan Province,China)

机构地区：[1]郑州大学第一附属医院介入科,河南省郑州市450000 [2]郑州大学第一附属医院骨科,河南省郑州市450000

出　　处：《内科》2022年第6期622-625,共4页Internal Medicine

摘　　要：目的研究含ω-3多不饱和脂肪酸(ω-3PUFA)的肠内免疫营养支持对老年原发性肝癌经导管动脉化疗栓塞(TACE)术后患者炎性因子水平、能量摄入和肠黏膜屏障功能的影响。方法选取109例老年原发性肝癌TACE术后患者作为研究对象,将其随机分为对照组(n=54)和观察组(n=55)。对照组行常规中长链脂肪乳剂肠外营养支持,观察组行含ω-3PUFA的肠内免疫营养支持,两组均连续干预14 d。比较两组患者干预期间每日能量摄入水平、干预前后炎性因子水平、肠黏膜屏障功能指标,以及术后并发症情况。结果干预5 d、7 d后,观察组每日能量摄入量、每日蛋白质摄入量均高于对照组(均P<0.05);干预14 d后,观察组血清白细胞介素(IL)-6、IL-8、D-乳酸、肠型脂肪酸结合蛋白水平均低于对照组(均P<0.05);观察组术后并发症总发生率低于对照组(P<0.05)。结论应用含ω-3PUFA的肠内免疫营养支持治疗老年原发性肝癌TACE术后患者,能够抑制炎性反应,提高能量摄入水平,改善肠黏膜屏障功能,降低术后并发症的发生率。Objective To investigate the effects of enteral immune nutrition support containingω-3 polyunsaturated fatty acid(ω-3PUFA)on inflammatory factors levels,energy intake,and intestinal mucosal barrier function in elderly primary liver cancer patients after transcatheter arterial chemoembolization(TACE).Methods A total of 109 elderly primary liver cancer patients after TACE were selected as research subjects and randomly divided into a control group(n=54)or an observation group(n=55).The control group was given conventional parenteral nutrition support with medium and long chain fat emulsion,the observation group was given enteral immune nutrition support containingω-3PUFA,and both groups were continuously intervened for 14 days.The everyday energy intake level during the intervention,inflammatory factors levels and intestinal mucosal barrier function indexes before and after intervention,and postoperative complications were compared between the two groups.Results Five days and 7 days after intervention,the everyday energy intake and everyday protein intake of the observation group were higher than those of the control group(all P<0.05).After 14 days of intervention,serum levels of interleukin(IL)-6,IL-8,D-lactic acid and intestinal fatty acid-binding protein of the observation group were lower than those of the control group(all P<0.05).The total incidence of postoperative complications in the observation group was lower than that in the control group(P<0.05).Conclusion The application of enteral immune nutrition support containingω-3PUFA in the intervention of elderly primary liver cancer patients after TACE can inhibit their inflammatory response,improve energy intake level,intestinal mucosal barrier function,and reduce the incidence of postoperative complications.

关 键 词：原发性肝癌 经导管动脉化疗栓塞 肠内营养 肠黏膜 屏障 炎性因子 能量摄入 

分 类 号：R735.7[医药卫生—肿瘤]