DNA倍体分析在口腔黏膜糜烂病损恶性变诊断中的应用  

DNA aneuploidy analysis in the diagnosis of oral mucosa erosion and malignant lesions

作　　者：李冬梅[1] 王志强[1] 夏鑫[1] 刘斌 苏晓路[2] LI Dongmei;WANG Zhiqiang;XIA Xin;LIU Bin;SU Xiaolu(Department of Stomatology,Lanzhou University Second Hospital,730030,China;Department of Pathology,Lanzhou University Second Hospital,730030,China)

机构地区：[1]兰州大学第二医院口腔科,730000 [2]兰州大学第二医院病理科,730000

出　　处：《实用口腔医学杂志》2023年第1期122-124,共3页Journal of Practical Stomatology

基　　金：甘肃省教育厅2020年甘肃省高等学校创新基金项目(编号:2020B-056);兰州大学第二医院萃英科技创新计划项目(编号:CY2019-BJ20);西北民族大学口腔医学国家民委重点实验室项目(编号:MWZD-201702)。

摘　　要：组织病理检查是口腔黏膜可疑癌前病变诊断的金标准,但病检有创伤、可重复性有限。脱落细胞DNA倍体分析因其微创、可重复性好,敏感性、特异性可靠,已用于口腔白斑等潜在恶性疾病的辅助诊断。该研究结合两种技术诊断口腔黏膜糜烂病损恶性变2例,为临床对该类疾病恶变早期预警,减少误诊、漏诊提供参考。Histopathology remains the golden standard for reporting cancer risk of oral potentially malignant disorders(OPMD), unfortunately it is invastive and has limited reproducibility.DNA aneuploidy cytometry of exfoliative epithelial cells is used as a noninvasive reproducible adjunctive diagnostic technique with higher sensitivity and specificity to oral leukoplakia(OLK).In this study, combination of the 2 techniques was used to diagnose 2 cases of oral mucosa erosion lesions with an increased risk of oral cancer, aimed to provide clinical reference for reducing misdiagnosis and missed diagnosis.

关 键 词：DNA倍体 糜烂 口腔鳞状细胞癌 

分 类 号：R739.8[医药卫生—肿瘤]