丁苯肽和长春西汀治疗急性缺血性脑卒中对患者血清LncRNA CAI2及CD62P的影响  

Effect of bufenopeptide combined with vinpocetine on serum levels of lncRNA CAI2 and CD62P in patients with acute ischemic stroke

作　　者：耿彪[1] 赵小辉[1] 宋志军 杨晶 刘盼 王洪志 马天骄 GENG Biao;ZHAO Xiaohui;SONG Zhijun(Baoding No.2 Central Hospital,Hebei,Baoding 072750,China;不详)

机构地区：[1]河北省保定市第二中心医院,072750 [2]河北省保定市清苑区人民医院

出　　处：《河北医药》2022年第24期3721-3724,3729,共5页Hebei Medical Journal

基　　金：保定市科学技术研究与发展计划项目(编号:2041ZF225)。

摘　　要：目的探究丁苯肽和长春西汀治疗急性缺血性脑卒中对患者血清长非编码RNA(long non coding RNA,LncRNA)CAI2及血小板膜激活标记物P-选择素(platelet membrane activation marker P-selectin,CD62P)的影响。方法选取2017年3月至2020年5月就诊并接受治疗的急性缺血性脑卒中患者220例,采用随机数字表法分为对照组和观察组,每组110例。对照组给予长春西汀,观察组给予丁苯肽结合长春西汀,对比2组治疗前后疗效、NIHSS评分、mRS评分和Barthel指数、血液流变学指标、血清炎性因子水平以及血清LncRNACAI2和CD62P水平。结果治疗后对照组的总有效率为89.1%,观察组的总有效率为96.4%,观察组总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗后2组NIHSS和mRS评分均显著降低(P<0.05),Barthel指数均显著提高(P<0.05)。此外,NIHSS评分和mRS评分均明显低于对照组(P<0.05),治疗后观察组的的Barthel指数明显高于对照组(P<0.05)。治疗后2组的血液流变学指标均明显降低(P<0.05),且观察组的血液流变学指标均明显低于对照组(P<0.05)。治疗后2组的血清炎性细胞因子水平均明显降低(P<0.05),且治疗后观察组的血清炎性细胞因子水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗后2组的血清LncRNACAI2和CD62P水平均显著降低(P<0.05),且2组间血清LncRNACAI2和CD62P水平的差异有统计学意义(P<0.05)。结论丁苯肽和长春西汀可能发生协同作用,增强溶栓和抗炎作用,可有效改善患者临床疗效,加快患者神经功能和生活自理能力恢复,改善血液流变学指标、血清炎性因子水平以及血清LncRNACAI2和CD62P水平。Objective To explore the expression levels of long non-coding RNA(lncRNA)CAI2 and P-selection(CD62P)in patients with acute ischemic stroke(AIS)treated with bufenopeptide combined with vinpocetine.Methods A total of 220 AIS patients treated in our hospital from March 2017 to May 2020 were randomly assigned in a 1∶1 ratio to receive vinpocetine(the control group)or bufenopeptide+vinpocetine(the observation group).The efficacy,the National Institutes of Health Stroke Scale(NIHSS),modified Rankin Scale(mRS)score,Barthel index,blood rheology indexes,inflammatory factors,and serum levels of lncRNA CAI2 and CD62P were compared between groups.Results After treatment,the total effective rate was significantly higher in the observation group than that of the control group(96.4%vs.89.1%,P<0.05).NIHSS and mRS scores of the two groups were significantly reduced,while the Barthel index was significantly enhanced after treatment(all P<0.05).In addition,the NIHSS score and mRS score of the observation group after treatment were significantly lower than those of the control group(both P<0.05),while the Barthel index of the observation group after treatment was significantly higher than that of the control group(P<0.05).The hemorheology indexes of the both groups were significantly reduced,which in the observation group were significantly lower than those of the control group(P<0.05).Serum levels of inflammatory cytokines were significantly reduced in the both groups,which were significantly lower in the observation group than those of the control group(P<0.05).Serum levels of lncRNA CAI2 and CD62P were significantly reduced in the both groups,and their differences between groups were statistically significant(both P<0.05).Conclusion Bufenopeptide combined with vinpocetine may have a synergistic effect on improving thrombolysis and preventing inflammatory response,which effectively improve the clinical efficacy,recovery of neurological function,self-care ability,blood rheology indicators and serum levels of inflammatory factors,

关 键 词：急性缺血性脑卒中 长春西汀 丁苯肽 血清长非编码RNA CAI2 血小板膜激活标记物P-选择素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]