胃神经内分泌肿瘤的分型和治疗研究进展  

Research progress of the typing and treatment of gastric neuroendocrine neoplasm

作　　者：徐梦娇 廖应英[1] 孙泽群[1] XU Mengjiao;LIAO Yingying;SUN Zequn(Department of Digestive System Diseases,Shiyan People’s Hospital Affiliated to Hubei Medicine and Pharmacy College,Hubei,Shiyan 442000,China;不详)

机构地区：[1]湖北医药学院附属十堰市人民医院消化内科,442000

出　　处：《河北医药》2022年第24期3791-3796,共6页Hebei Medical Journal

基　　金：十堰市科技局引导性科研项目(编号:21Y62)。

摘　　要：胃神经内分泌肿瘤(gastric neuroendocrine neoplasm,G-NENs)是一类起源于胃黏膜肠嗜铬细胞的一类罕见且可变的异质性肿瘤,是一种惰性肿瘤,也可以具有侵袭性和广泛转移等生物学行为。过去由于发生率低没有引起人们足够重视,随着上消化道内镜普及、技术的提高,越来越多的人认识到G-NENs,检出率提高,大多数G-NETs在行内窥镜检查时偶然发现单纯的胃息肉。2019年世界卫生组织WHO提出胃肠胰神经内分泌肿瘤分级分类的新三型分类。本文对G-NENs各亚型流行病学、临床分型、组织学分级以及治疗方法等最新进展进行综述,以期对今后的治疗提供参考。Gastric Neuroendocrine Neoplasm(G-NENs)is a rare and variable heterogeneous tumor originating from chromaffin cells in the stomach mucosa and intestine,whichj is an inert tumor and may have biological behaviors including invasion and extensive metastasis.In the past,people did not pay much attention to the low incidence of the disease.At present,with the popularization and improvement of upper gastrointestinal endoscopy,more and more people are aware of G-NENs,and the detection rate is increasing.Most G-Nets occasionally find simple gastric polyps during endoscopy.In 2019,the World Health Organization(WHO)proposed a new three-type classification of gastrointestinal pancreatic neuroendocrine neoplasms.This article reviews the latest advances in the epidemiology,clinical classification,histological classification and treatment of G-NENs subtypes,in order to provide reference for future treatment.

关 键 词：胃神经内分泌肿瘤 分型 高胃泌素血症 卓艾综合征治疗 

分 类 号：R735[医药卫生—肿瘤]