薯蓣皂苷治疗肝脏疾病作用的研究进展  

Research progress on the action mechanism of dioscin in treatment of liver diseases

作　　者：黄楠楠[1] 林佳艳 吴丽红[1] 孟鑫[1] 杨德强[1] HUANG Nannan;LIN Jiayan;WU Lihong(Heilongjiang TCM University,Heilongjiang,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,哈尔滨市150040

出　　处：《河北医药》2022年第24期3797-3801,共5页Hebei Medical Journal

基　　金：黑龙江省中医药管理局项目(编号:ZHY18-046);黑龙江中医药大学大学生科技创新实验项目(编号:2020-12)。

摘　　要：肝脏是人体进行物质合成及能量转换的主要器官,出现损伤将影响机体的正常生理功能。酒精、药物不良反应和肥胖诱发的脂肪性疾病等会导致肝脏有不同程度的损伤,甚至产生不可逆的结果,因此,迫切需要探索和开发有效的保肝候选药物。大量研究表明,薯蓣皂苷作为天然活性物质,对肝脏疾病的治疗具有显著的效果。本文对薯蓣皂苷治疗肝脏疾病的作用机制进行了概述总结,主要是通过调节多个靶点和生物过程等发挥强大的保肝作用,为薯蓣皂苷治疗肝脏疾病提供重要的理论基础。The liver is the main organ of the body for material synthesis and energy conversion,any injury to it will affect the normal physiological function of the body.The steatosis induced by steatosis alcohol,adverse drug reactions and obesity can lead to varying degrees of liver damage,even result in irreversible results.Therefore,it is necessary to explore and develop effective hepatoprotective drug candidates.A lot of researches have shown that dioscin,as an natural active substance,has significant effects in treatment of liver diseases.This article reviews the action mechanism of dioscin in treatment of liver diseases,which may exert powerful hepatoprotective effects by modulating multiple targets and biological processes,moreover,the article will provide an important theoretical basis for the application of dioscin in treatment of liver diseases.

关 键 词：薯蓣皂苷 肝脏疾病 作用机制 

分 类 号：R575[医药卫生—消化系统]