The Roles and Mechanisms of TRAT1 in the Progression of Non-Small Cell Lung Cancer  

作　　者：Qiang GUO Si-hua WANG Yan-mei JI Song TONG Dan LI Xiang-chao DING Chuang-yan WU 

机构地区：[1]Department of Thoracic Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China [2]Department of Neurocritical Care Medicine,Taihe Hospital,Hubei University of Medicine,Shiyan,442000,China [3]Department of Oncology,Huanggang Central Hospital Affiliated to Yangtze University,Huanggang,438000,China [4]Department of Thoracic Surgery,Renmin Hospital of Wuhan University,Wuhan,430060,China

出　　处：《Current Medical Science》2022年第6期1186-1200,共15页当代医学科学（英文）

基　　金：supported by grants from the Natural Science Foundation of Hubei(No.2020CFB392);the National Natural Science Foundation of China(No.82100115,No.82100116 and No.82070431).

摘　　要：Objective T cell receptor-associated transmembrane adaptor 1(TRAT1)is one of the hub genes regulating T cell receptors(TCRs).Herein,the roles of TRAT1 in the prognosis and immune microenvironment of non-small cell lung cancer(NSCLC)were investigated.Methods The expression and prognosis values of TRAT1 in NSCLC,and the relationship between TRAT1 expression levels and cancer immune cell infiltration was identified via the TIMER,UALCAN,TISIDB,and other databases.The mechanism of TRAT1 in NSCLC was analyzed using gene set enrichment analysis(GSEA).Results The expression level of TRAT1 was decreased in NSCLC tissues.Low TRAT1 expression was associated with shorter overall survival of patients with NSCLC and was related to gender,smoking,and tumor grade.TRAT1 was involved in regulating immune response,TCR signaling pathway,PI3K/AKT,and other processes.TRAT1 expression levels were positively correlated with immune cell infiltration in NSCLC.Conclusion Down-regulation of TRAT1 expression was associated with an unfavorable prognosis and immune infiltration of NSCLC.

关 键 词：T cell receptor-associated transmembrane adaptor 1 non-small cell lung cancer immune infiltration prognosis T cell receptors 

分 类 号：R734.2[医药卫生—肿瘤]