血管生成素样蛋白4与新生血管性眼底疾病发病机制关系的研究进展  

Research progress of the relationship between angiopoietin-like 4 and the pathogenesis of neovascular ocular fundus disease

作　　者：吴东亭 郑磊[2] 张国明[2] Wu Dongting;Zheng Lei;Zhang Guoming(The Second Clinical Medical College of Jinan University,Shenzhen 518020,China;Shenzhen Eye Hospital,Shenzhen Eye Hospital Affiliated to Jinan University,Shenzhen Eye Institute,Shenzhen 518040,China)

机构地区：[1]暨南大学第二临床医学院,深圳518020 [2]深圳市眼科医院、暨南大学附属深圳眼科医院、深圳市眼病防治研究所,518040

出　　处：《国际眼科纵览》2022年第6期535-540,共6页International Review of Ophthalmology

基　　金：国家自然科学基金(82003794);广东省高水平临床重点专科(深圳市配套建设经费)(SZGSP014);深港联合资助项目(A类)(SGDX20190920110403741);深圳市医学重点学科建设经费资助项目(SZXK038);深圳市科技计划项目基础研究(面上项目)(JCYJ20190808170609490)。

摘　　要：血管生成素样蛋白4(angiopoietin-like 4,ANGPTL4)是近年来发现的一种多功能蛋白质,其参与调控糖脂代谢、促进血管生成、调节血管通透性等生物过程。ANGPTL4与糖尿病视网膜病变、视网膜血管阻塞性疾病、年龄相关性黄斑变性等眼底新生血管性疾病的发生有关。在高糖、缺氧等因素的作用下,ANGPTL4表达上调,进而诱导病理性新生血管生成并增加血管通透性。有望未来成为多种新生血管性眼底疾病的诊断标志物及潜在治疗靶点。Angiopoietin-like 4(ANGPTL4)is a recently discovered multifunctional protein involved in the regulation of glucose,lipid metabolism,angiogenesis,vascular permeability and other biological processes.ANGPTL4 is closely linked with the mechanism of neovascular ocular fundus disease such as diabetic retinopathy,retinal vascular occlusive disease,and age-related macular degeneration and so on.The expression of ANGPTL4 is up-regulated by high glucose and hypoxia,which induces a series of pathological events occurred including angiogenesis and increase vascular permeability.It is expected to become a diagnostic biomarker and potential therapeutic target for neovascular fundus diseases in the future.

关 键 词：血管生成素样蛋白4 新生血管性眼底疾病 促血管生成因子 

分 类 号：R77[医药卫生—眼科]