胃癌组织TIP30、KAI-1蛋白表达与胃癌根治术后复发的关系分析  

Relationships between TIP30,KAI-1 protein expressions and recurrence after radical gastrectomy in gastric cancer

作　　者：高振 林剑鹏 王永锋 陆欢华 GAO Zhen;LIN Jianpeng;WANG Yongfeng;LU Huanhua(Department of General Surgery,Qingpu Branch,Zhongshan Hospital Affiliated to Fudan University,Shanghai 201700,China)

机构地区：[1]复旦大学附属中山医院青浦分院普外科,上海201700

出　　处：《检验医学与临床》2023年第4期433-437,共5页Laboratory Medicine and Clinic

摘　　要：目的分析胃癌组织Tat作用蛋白30(TIP30)、转移抑制基因1(KAI-1)蛋白表达与根治术后复发的关系。方法选取该院2019年1月至2020年7月收治的实施根治术的119例胃癌患者为研究对象,采用免疫组化法分别检测癌组织、癌旁组织TIP30、KAI-1蛋白表达。比较癌组织与癌旁组织TIP30、KAI-1蛋白阳性表达率;比较不同特征患者癌组织TIP30、KAI-1蛋白阳性表达率。将癌组织TIP30、KAI-1蛋白表达作为自变量,采用Logistic回归分析胃癌患者根治术后复发的影响因素。结果胃癌组织TIP30、KAI-1蛋白阳性表达率分别为34.51%、29.20%,癌旁组织分别为73.45%、75.22%,前者均低于后者,差异有统计学意义(P<0.05);临床分期Ⅲ~Ⅳ期、有淋巴结转移、浸润浆膜层、未/低分化患者癌组织TIP30、KAI-1蛋白阳性表达率均分别低于Ⅰ~Ⅱ期、无淋巴结转移、未浸润浆膜层、中/高分化患者,差异有统计学意义(P<0.05);胃癌根治术后复发率为23.01%,且临床分期Ⅲ~Ⅳ期、有淋巴结转移、浸润浆膜层、未/低分化均是其危险因素(OR=5.468、7.207、6.265、8.559,P<0.05),癌组织TIP30阳性表达、癌组织KAI-1蛋白阳性表达、术后规范治疗均是其保护因素(OR=0.591、0.480、0.560,P<0.05)。结论胃癌组织TIP30、KAI-1蛋白阳性表达率较癌旁组织降低,与临床分期、淋巴结转移情况、浸润程度、肿瘤分化程度均有关,且上述指标与术后是否规范治疗均可影响根治术后复发。Objective To analyze the relationships between the expressions of Tat action protein 30(TIP30),metastasis suppressor gene 1(KAI-1)protein and recurrence after radical gastrectomy.Methods A total of 119 patients with gastric cancer who underwent radical gastrectomy in Qingpu Branch,Zhongshan Hospital Affiliated to Fudan University from January 2019 to July 2020 were selected,and the expressions of TIP30 and KAI-1 protein in cancer tissue and paracancer tissue were detected by immunohistochemistry.The positive expression rates of TIP30 and KAI-1 protein in cancer tissue and paracancer tissue were compared.The positive expression rates of TIP30 and KAI-1 protein in cancer tissue of patients with different characteristics were compared.Taking the expressions of TIP30 and KAI-1 protein in cancer tissue as independent variables,Logistic regression analysis was used to explore the influencing factors of recurrence after radical resection.Results The positive expression rates of TIP30 and KAI-1 protein in gastric cancer tissue were 34.51%and 29.20%respectively,and 73.45%and 75.22%in paracancer tissue respectively,of which the former was lower than the latter(P<0.05).The positive expression rates of TIP30 and KAI-1 protein in cancer tissue of patients with clinical stageⅢ-Ⅳ,lymph node metastasis,serosal invasion and undifferentiated/poorly differentiated were lower than those of patients with stageⅠ-Ⅱ,no lymph node metastasis,non serosal invasion and medium/highly differentiated(P<0.05).The recurrence rate after radical gastrectomy was 23.01%,and clinical stageⅢ-Ⅳ,lymph node metastasis,serosa infiltration and non/poor differentiation were the risk factors(OR=5.468,7.207,6.265,8.559,P<0.05),while the positive expression of TIP30,KAI-1 protein and postoperative standard treatment were the protective factors(OR=0.591,0.480,0.560,P<0.05).Conclusion The positive expression rates of TIP30 and KAI-1 protein in gastric cancer tissue are lower than those in paracancer tissue,which relate to clinical stage,lymph node me

关 键 词：胃癌 Tat作用蛋白30 转移抑制基因1 胃癌根治术 复发 

分 类 号：R735.2[医药卫生—肿瘤]