结直肠癌患者血清LMTK3、SCC-Ag水平与异时性肝转移的相关性  

Correlations between serum levels of LMTK3 and SCC-Ag in patients with colorectal cancer complicated with metachronous liver metastasis

作　　者：王晓勇 刘艳霞 WANG Xiaoyong;LIU Yanxia(Department of Internal Oncology,Xianyang Cancer Hospital,Xianyang,Shaanxi 712044,China;First Department of Internal Medicine,Caihong Hospital,Xianyang,Shaanxi 712021,China)

机构地区：[1]咸阳肿瘤医院肿瘤内科,陕西咸阳712044 [2]彩虹医院内一科,陕西咸阳712021

出　　处：《检验医学与临床》2023年第4期438-441,共4页Laboratory Medicine and Clinic

摘　　要：目的分析结直肠癌(SCC)患者血清狐猴酪氨酸激酶-3(LMTK3)、鳞状细胞癌抗原(SCC-Ag)水平与异时性肝转移的相关性。方法选择2019年1月至2021年1月咸阳肿瘤医院收治的80例SCC患者为研究对象,根据患者是否发生异时性肝转移分为未转移组及转移组,比较两组年龄、肿瘤最大径、TNM分期等临床指标,采集两组患者清晨空腹静脉血,采用酶联免疫吸附试验检测血清LMTK3水平,采用电化学发光法检测血清SCC-Ag水平,采用Spearman相关分析血清LMTK3、SCC-Ag水平与临床指标的相关性,采用Logistic回归分析SCC患者发生异时性肝转移的危险因素。结果转移组肿瘤最大径>3 cm、肿瘤浸润程度为T3~T4、分化程度低、有淋巴结转移、TNM分期为Ⅲ~Ⅳ期患者比例明显高于未转移组,差异有统计学意义(P<0.05)。发生异时性肝转移的SCC患者血清LMTK3水平与TNM分期、肿瘤最大径、淋巴结转移呈正相关(r=0.512、0.385、0.474,P<0.05);发生异时性肝转移的SCC患者血清SCC-Ag水平与TNM分期、肿瘤最大径、淋巴结转移呈正相关(r=0.411、0.538、0.395,P<0.05)。LMTK3及SCC-Ag水平升高、TNM分期为Ⅲ~Ⅳ期、肿瘤最大径>3 cm、有淋巴结转移均为SCC患者发生异时性肝转移的独立危险因素(P<0.05)。结论SCC患者血清LMTK3、SCC-Ag水平异常升高是SCC患者发生异时性肝转移的独立危险因素,有助于评估SCC患者发生异时性肝转移的趋向。Objective To analyze the correlations between serum lemur tyrosine kinase-3(LMTK3)and squamous cell carcinoma antigen(SCC-Ag)in patients with colorectal cancer(SCC)complicated with metachronous liver metastasis.Methods A total of 80 patients with SCC admitted to Xianyang Cancer Hospital from January 2019 to January 2021 were collected as research objects.They were divided into the non-metastatic group and the metastatic group according to whether the patients had metachronous liver metastasis.Clinical indicators such as age,maximum tumor diameter and TNM stage were compared between the two groups,and fasting venous blood was collected in the morning from patients in the two groups.Serum LMTK3 level was detected by enzyme-linked immunosorbent assay,serum SCC-Ag level was detected by electrochemiluminescence assay,the correlations between serum LMTK3,SCC-Ag levels and clinical indicators were analyzed by Spearman correlation analysis,and the risk factors of metachronous liver metastasis in patients with SCC were analyzed by Logistic regression.Results The proportions of tumor maximum diameter>3 cm,degree of tumor invasion T3-T4,low degree of differentiation,lymph node metastasis and TNM stageⅢ—Ⅳin the metastasis group were significant higher than those in the non-metastasis group,the differences were statistically significant(P<0.05).Serum LMTK3 level correlated positively with TNM stage,maximum tumor diameter and lymph node metastasis in SCC patients with metachronous liver metastasis(r=0.512,0.385,0.474,P<0.05).Serum SCC-Ag level correlated positively with TNM stage,maximum tumor diameter and lymph node metastasis in SCC patients with metachronous liver metastasis(r=0.411,0.538,0.395,P<0.05).Increased levels of LMTK3 and SCC-Ag,TNM stageⅢ—Ⅳ,maximum tumor diameter>3 cm and lymph node metastasis were independent risk factors for metachronous liver metastasis in SCC patients(P<0.05).Conclusion Abnormal increase of serum LMTK3 and SCC-Ag levels were independent risk factors affecting the occurrence of met

关 键 词：结直肠癌 狐猴酪氨酸激酶-3 鳞状细胞癌抗原 异时性肝转移 

分 类 号：R735[医药卫生—肿瘤] R446.9[医药卫生—临床医学]