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作 者:金萍 韩煦[1] 杨晓蕾[1] 夏云龙[1] JIN Ping;HAN Xu;YANG Xiaolei;XIA Yunlong(Cardiovascular Hospital,The First Affiliated Hospital of Dalian Medical University,Dalian 116011,Liaoning,China)
机构地区:[1]大连医科大学附属第一医院心血管病医院,辽宁大连116011
出 处:《心血管病学进展》2023年第1期51-56,共6页Advances in Cardiovascular Diseases
摘 要:雄激素能刺激前列腺肿瘤细胞的生长和分裂。前列腺癌的内分泌治疗主要是降低血液中的雄激素水平或在细胞水平拮抗雄激素的作用。随着内分泌治疗药物广泛而持久的应用,对其心血管毒副作用的研究也不断深入。但目前仍缺乏来自前瞻性设计临床试验的可靠安全的数据支撑。此外,现已发表的关于前列腺癌患者内分泌治疗和心血管疾病之间关系的研究结论相互矛盾。因此,现总结临床常见的新旧内分泌治疗药物如促性腺激素释放激素激动剂或拮抗剂、雄激素受体抑制剂、CYP17抑制剂等与心血管疾病之间的关系。Androgens stimulate the growth and division of prostate cancer cells.Endocrine therapy for prostate cancer is mainly to reduce androgens in the serum or antagonize the effect of androgens at the cellular level.The widespread and prolonged use of hormonal treatments has led to increased interest in their potential associated risks of cardiovascular toxicities.But there is still a lack of reliable safety data from prospectively designed clinical trials.Published data on the association between endocrine therapy and cardiovascular disease in patients with prostate cancer are conflict.In this review,we summarize the relationship between clinical common new and old endocrine therapy agents such as gonadotropin-releasing hormone agonists or antagonists,androgen receptor inhibitors,CYP17 inhibitors and cardiovascular disease.
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