红花注射液穴位离子导入联合康柏西普治疗视网膜静脉阻塞并黄斑水肿的临床效果  

Effect of Honghua injection acupiont iontophoresis combined with Conbercept on retinal vein occlusion with macular edema

作　　者：李婧 刘素勤 谢爱宏 刘伟双 杨磊 LI Jing;LIU Suqin;XIE Aihong;LIU Weishuang;YANG Lei(Department of Ophthalmology,PingKuang General Hospital,Jiangxi Province,Pingxiang337000,China)

机构地区：[1]江西省萍乡矿业集团有限责任公司总医院眼科,江西萍乡337000

出　　处：《中国当代医药》2023年第5期126-129,133,共5页China Modern Medicine

基　　金：江西省中医药科研课题(2019A376)。

摘　　要：目的研究红花注射液眼部穴位离子导入联合康柏西普玻璃体腔注射治疗视网膜静脉阻塞(RVO)并黄斑水肿(ME)的临床效果及安全性。方法选取2019年9月至2021年12月萍乡矿业集团有限责任公司总医院收治的56例(56眼)诊断为RVO并ME的患者作为研究对象,按照随机数字表法分为观察组(28例28眼)与对照组(28例28眼),对照组脱落2例,最终纳入26例(26眼)。对照组行玻璃体腔康柏西普注射,观察组加用红花注射液穴位离子导入眼内治疗。治疗观察时间为3个月,比较两组患者治疗前后最佳矫正视力(BCVA)、黄斑中心视网膜厚度(CMT)、视网膜静脉循环时间、需要玻璃体腔药物注射的次数和不良反应。结果两组患者在治疗后2周、1、2、3个月BCVA有提高,CMT有降低,差异均有统计学意义(P<0.05),观察组治疗后2、3个月BCVA高于对照组,观察组治疗后2、3个月CMT低于对照组,差异有统计学意义(P<0.05);两组患者在治疗后3个月视网膜静脉循环时间较治疗前缩短,观察组治疗后3个月视网膜静脉循环时间短于对照组,差异有统计学意义(P<0.05);观察组康柏西普注药次数少于对照组,差异有统计学意义(P<0.05);两组患者治疗中不良反应总发生率比较,差异无统计学意义(P>0.05)。结论红花穴位离子导入联合康柏西普治疗RVO并ME疗效更为显著,在短期内可以提高患者视力、减轻ME、改善视网膜静脉循环,且未发生严重并发症,安全性高。Objective To study the clinical effect and safety of acupiont iontophoresis of Honghua injection combined with Conbercept in the treatment of retinal vein obstruction(RVO)with macular edema(ME).Methods A total of 56 patients(56 eyes)with RVO and ME who were diagnosed in PingKuang General Hospital from September 2019 to December 2021 were selected as the research subjects.According to the random number table method,they were divided into the observation group(28 eyes in 28 cases)and the control group(26 eyes in 26 cases).The control group lost 2 cases,and finally included 26 cases(26 eyes).The control group was treated with intraviteal injection of Conbercept,and the observation group was treated with Conbercept combined with the acupiont iontophoresis of Honghua injection.Both group were treated and followed up for 3month.The best corrected visual acuity(BCVA),the cental maclur thickness(CMT),the retinal venous circulation time,the injection frequencies of conbercept and the complications were observed and compared between the two groups before and after treatment.Results After 2 weeks,1,2,3 months of treatment,the BCVA of the two groups was improved while the CMT was thinned,the differences were statistically significant(P<0.05).The BCVA on the 2 and 3 month of treatment in observation group were better than those in control group,while the CMT was thinner than that in control group,the differences were statistically significant(P<0.05).The retinal venous circulation time was reduced in the two groups after 3 months'treatment,and the retinal venous circulation time on the observation group was shorter than that in control group after 3 months of treatment,the differences were statistically significant(P<0.05).The injection frequencies of Conbercept on the observation group was less than that in control group after treatment,the difference was statistically significant(P<0.05).There was no significantly difference in the total incidence of adverse reactions between the two groups during the treatment(P>0.05).Conc

关 键 词：红花注射液 康柏西普 穴位离子导入 视网膜静脉阻塞 黄斑水肿 

分 类 号：R774.1[医药卫生—眼科]