轻型缺血性脑卒中后认知障碍及其危险因素分析  

Analysis of cognitive impairment and its risk factors after minor ischemic stroke

作　　者：陈明濠 谢伟坚 梅麒 张业昆 黄炬辉 CHEN Minghao;XIE Weijian;MEI Qi;ZHANG Yekun;HUANG Juhui(Department of Neurology,Panyu District Hexian Memorial Hospital,Panyu District Maternal and Child Health Care Hospital,Guangzhou 511400,Guangdong,China)

机构地区：[1]广州市番禺区何贤纪念医院,番禺区妇幼保健院神经内科,广东广州511400

出　　处：《中南医学科学杂志》2023年第1期136-138,共3页Medical Science Journal of Central South China

基　　金：番禺区科技计划项目(2020-204-107)。

摘　　要：目的 分析轻型缺血性脑卒中患者发生认知障碍的情况及其危险因素。方法 选取轻型缺血性脑卒中患者198例,随访6~12个月,根据简易精神状态量表(MMSE)分为卒中后认知功能障碍(PSCI)组和卒中后认知正常(PSCN)组,比较两组患者血生化指标以及卒中病灶部位等指标。结果 198例脑卒中患者中,105例患者出现认知功能障碍,PSCI发病率为53.03%。PSCI组患者年龄、空腹血糖、超敏C反应蛋白、NIHSS评分、脑梗死病史发生率以及脑白质疏松发生率均高于PSCN组(P<0.05)。与PSCN组比较,PSCI组额叶、顶叶、颞叶、枕叶梗死部位患者PSCI发生率更高(P<0.05)。经Logstic回归分析发现,年龄、脑梗死以及脑梗死部位是PSCI的危险因素(P<0.05)。结论 轻型缺血性脑卒中后PSCI发生率较高,年龄、脑梗死以及脑梗死部位是其危险因素。Aim To analyze the cognitive impairment and its risk factors in patients with mild ischemic stroke.Methods 198 patients with cerebral infarction were selected, followed up for 6 to 12 months, and were divided into the post-stroke cognitive impairment group(PSCI) according to the Mini Mental State Scale(MMSE) and the post-stroke cognitive normal group(PSCN), and the general clinical data, blood biochemical indexes, and stroke lesions were compared between the two groups. Results Among the 198 stroke patients in this study, 105 patients had cognitive dysfunction, and the incidence of PSCI was 53.03%. The age, fasting blood glucose, hypersensitivity C-reactive protein, and NIHSS scores, the incidence of cerebral infarction history and the incidence of leukoaraiosis in the PSCI group were higher than those in the PSCN group(P<0.05). Compared with the PSCN group, the incidence of PSCI in the frontal, parietal, temporal, and occipital lobe infarcts was higher in the PSCI group(P<0.05). Logstic regression showed that age, cerebral infarction and location of cerebral infarction were risk factors for PSCI(P<0.05). Conclusion The incidence of PSCI after minor ischemic stroke is high, and age, cerebral infarction and location of cerebral infarction are its risk factors.

关 键 词：轻型缺血性脑卒中 认知功能障碍 简易精神状态量表 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]