纳米颗粒影响心血管健康的分子机制研究进展  

Advances in the molecular mechanisms underlying the effects of nanoparticles on cardiovascular health

作　　者：陈舒婷 黄方方 冯雅诗 张钰棋 王五香[3] 封少龙 CHEN Shuting;HUANG Fangfang;FENG Yashi;ZHANG Yuqi;WANG Wuxiang;FENG Shaolong(The School of Public Health,Hengyang Medical School,University of South China,Hengyang 421001,Hunan,China;Institute of Preventive Medicine,Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health,School of Public Health,Guilin Medical University,Guilin 541199,Guangxi,China;The Library,University of South China,Hengyang 421001,Hunan,China;The State Key Laboratory of Organic Geochemistry,Guangzhou Institute of Geochemistry,Chinese Academy of Sciences,Guangzhou 510640,Guangdong,Chin)

机构地区：[1]南华大学衡阳医学院公共卫生学院,湖南衡阳421001 [2]桂林医学院公共卫生学院,广西环境暴露组学与全生命周期健康重点实验室,预防医学研究所,广西桂林541199 [3]南华大学图书馆,湖南衡阳421001 [4]中国科学院广州地球化学研究所,有机地球化学国家重点实验室,广东广州510640

出　　处：《中南医学科学杂志》2023年第1期142-145,共4页Medical Science Journal of Central South China

基　　金：国家自然科学基金(41877390);有机地球化学国家重点实验室开放基金(SKLOG-202010)。

摘　　要：纳米颗粒可致心血管细胞生理结构改变及功能紊乱,甚至促使细胞死亡,进而导致心血管系统组织结构重塑和功能异常,诱发心血管病事件。纳米颗粒影响心血管健康的分子机制主要有氧化应激、遗传毒性、线粒体损伤、内质网应激、抑制自噬、诱导炎症、扰乱Ca2+信号和干扰脂代谢等。本文综述了纳米颗粒影响心血管健康的分子机制,为生态环境部门的科学决策提供依据。Nanoparticles may alter the physiological structure of cells in the cardiovascular system and in turn lead to their dysfunction, and even promote cell death, which can lead to structural remodeling and dysfunction of the cardiovascular system, and induce cardiovascular events. The molecular mechanisms by which nanoparticles affect the cardiovascular health mainly include: oxidative stress, genotoxicity, mitochondrial damages, endoplasmic reticulum stress, blocking autophagic flux, inducing inflammation, disturbing Ca2+signaling and lipid metabolism. In this paper, the molecular mechanisms underlying the effects of nanoparticles on cardiovascular health were reviewed, in order to provide a basis for the scientific decision-making by the ecological and environmental departments.

关 键 词：纳米颗粒 心血管系统 健康 毒理学 

分 类 号：R-1[医药卫生]