睾酮合成的表观遗传调控机制研究进展  

Research Progress on the Epigenetic Regulation Mechanism of Testosterone Synthesis

作　　者：安雯 赵静[1,2,3] 王军 吕文发[1,2,3] AN Wen;ZHANG Jing;WANG Jun;LYU Wenfa(Joint Key Laboratory of International Cooperation for Modern Agricultural Technology,Ministry of Education,Jilin Agricultural University,Jilin Changchun 130118,China;Key Laboratory of Animal Production and Product Quality and Safety of Ministry of Education,Jilin Agricultural University,Jilin Changchun 130118,China;College of Animal Science and Technology,Jilin Agricultural University,Jilin Changchun 130118,China)

机构地区：[1]吉林农业大学现代农业技术教育部国际合作联合重点实验室,吉林长春130118 [2]吉林农业大学动物生产及产品质量安全教育部重点实验室,吉林长春130118 [3]吉林农业大学动物科学技术学院,吉林长春130118

出　　处：《中国畜牧杂志》2023年第1期65-70,共6页Chinese Journal of Animal Science

基　　金：国家重点研发计划项目(2018YFE0122000);吉林省中青年科技创新领军人才及团队(20200301031RQ);财政部和农业农村部:国家现代农业产业技术体系建设专项(CARS-37)。

摘　　要：睾酮是一种主要由睾丸间质细胞合成分泌的类固醇激素,参与调节生殖和其他生理活动,对精子发生及维持雄性生殖健康具有重要作用。睾酮合成是一个非常复杂的过程,受到激素、转录因子及信号转导等调控。表观遗传是在基因序列不变的基础上基因表达发生的可遗传变化,其主要类型包括DNA甲基化、组蛋白甲基化、组蛋白乙酰化、组蛋白泛素化、非编码RNA和RNA甲基化调控等。表观遗传作为睾酮合成的重要调节途径,近年来越来越受关注。本文简要介绍了表观遗传对睾酮合成的调控,总结了DNA甲基化、组蛋白甲基化、组蛋白乙酰化、组蛋白泛素化、非编码RNA和RNA甲基化调控睾酮合成的相关研究进展,以期为进一步研究睾酮合成机制提供参考。Testosterone is a steroid hormone synthesized and secreted by Leydig cells, which participates in regulating reproductive and other physiological activities, and is of great significance for spermatogenesis and maintenance of male reproductive health. Testosterone synthesis is a very complex process, which is regulated by hormones, transcription factors and signal transduction. Epigenetic are heritable changes in gene expression that occur on the basis of a constant gene sequences, its main types include DNA methylation, histone methylation, histone acetylation, histone ubiquitination,non-coding RNA and RNA methylation. Epigenetics, have attracted more and more attention in recent years as important regulatory pathways of testosterone synthesis. This paper briefly introduces the epigenetic regulation in testosterone synthesis,analyzes and summarizes the related research progress of DNA methylation, histone methylation, histone acetylation, histone ubiquitination, noncoding RNA and RNA methylation in the regulation in testosterone synthesis, which look forward to the further study on the mechanism of testosterone synthesis.

关 键 词：睾酮 DNA甲基化 组蛋白修饰 非编码RNA RNA甲基化 

分 类 号：X173[环境科学与工程—环境科学]