正常眼压性青光眼患者黄斑区血流灌注状态与视野缺损的相关性研究  

Correlation between macular blood flow perfusion and visual field defect in patients with normal tension glaucoma

作　　者：郑嘉琦 俞莹[1] ZHENG Jiaqi;YU Ying(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院,上海201203 [2]银川市中医院,银川750001

出　　处：《中国中医眼科杂志》2023年第2期123-126,共4页China Journal of Chinese Ophthalmology

基　　金：上海市中医专科培育项目。

摘　　要：目的观察正常眼压性青光眼(NTG)患者黄斑区血流灌注状态,分析其与视野缺损之间的相关性。方法纳入2020年1月—2021年2月就诊于上海中医药大学附属曙光医院的符合纳入标准的NTG患者70例(70只眼)作为观察组,选取同期同医院就诊的同年龄段的健康志愿者49例(49只眼)作为对照组。采集受试者黄斑区视网膜浅层血管线性密度(MSRVLD)、黄斑区视网膜浅层血管灌注密度(MSRPD)、黄斑中心凹无血管区面积(FAZ)及观察组患者的视野平均缺损(MD),并对以上数据进行统计学分析。结果(1)MSRVLD:观察组黄斑区下方及鼻侧较对照组下降,差异均有统计学意义(t_(下方)=4.041,P=0.000;t_(鼻侧)=2.945,P=0.004)。(2)MSRPD:观察组黄斑区下方及鼻侧较对照组下降,差异均有统计学意义(t_(下方)=3.291,P=0.001;t_(鼻侧)=2.924,P=0.004)。(3)黄斑中心凹FAZ:观察组黄斑中心凹FAZ面积为(0.21±0.13)mm^(2),对照组为(0.23±0.17)mm^(2)。2组比较,差异无统计学意义(P>0.05)。(4)相关性分析:观察组MD与MSRVLD、MSRPD呈正相关(r_(MSRVLD)=0.387,r_(MSRPD)=0.402,均P=0.001)。结论NTG患者黄斑区存在血流灌注不足,且与MD相关。OBJECTIVE To observe the macular blood flow perfusion in patients with normal tension glaucoma(NTG)and analyze its correlation with visual field defect.METHODS A total of 70 cases(70 eyes)of NTG patients who met the inclusion criteria and visited Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine(TCM)from January 2020 to February 2021 were included as the observation group,and 49 cases(49 eyes)of healthy volunteers of the same age in the same hospital during the same period were selected as the control group.Macular superficial retinal vessel length density(MSRVLD),macular superficial retinal perfusion density(MSRPD),and foveal avascular zone(FAZ)of all the subjects as well as the mean visual field defect(MD)of the observation group were collected and statistically analyzed.RESULTS(1)MSRVLD:MSRVLD of the lower and nasal part of the macular area of the observation group were lower than those of the control group,and the differences were statistically significant(t_(lower)=4.041,P=0.000;t_(nasal)=2.945,P=0.004).(2)MSRPD:MSRPD of the lower and nasal part of the macular area of the observation group were lower than those of the control group,and the differences were statistically significant(t_(lower)=3.291,P=0.001;t_(nasal)=2.924,P=0.004).(3)Macular fovea FAZ:The FAZ area of macular fovea in the observation group was(0.21±0.13)mm2,and that in the control group was(0.23±0.17)mm2.There was no significant difference between the two groups(P>0.05).(4)Correlation analysis:MD in the observation group was positively correlated with MSRVLD and MSRPD(r_(MSRVLD)=0.387,r_(MSRPD)=0.402,both P=0.001).CONCLUSIONS There is insufficient blood flow perfusion in the macular region of NTG patients,which is related to MD.

关 键 词：正常眼压性青光眼 视网膜浅层血流灌注 视野平均缺损 黄斑区视网膜浅层血管线性密度 黄斑区视网膜浅层血管灌注密度 黄斑中心凹无血管区面积 

分 类 号：R775.5[医药卫生—眼科]