NF-κB信号通路在变态反应性结膜炎中的研究进展  

The research progress of the NF-κB signaling pathway in allergic conjunctivitis

作　　者：田梓廷 孙河[2] TIAN Ziting;SUN He(Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]黑龙江中医药大学附属第一医院,哈尔滨150040

出　　处：《中国中医眼科杂志》2023年第2期175-177,195,共4页China Journal of Chinese Ophthalmology

基　　金：全国名老中医药专家(孙河)传承工作室项目。

摘　　要：核因子κB(NF-κB)信号通路广泛存在于哺乳动物细胞中,其可以调节免疫细胞的生成、发育和活性,被证实能够影响诸多变态反应性疾病及炎症疾病的进展。变态反应性结膜炎作为一种变态反应与炎症反应并存的超敏疾病,也受NF-κB信号通路的调节。本文依据NF-κB信号通路在变态反应性结膜炎中的作用的研究进展,发现NF-κB信号通路可能通过炎症反应、角结膜重塑及新生血管、免疫反应等途径影响变态反应性结膜炎,其相关靶点和药物具有广阔的研究空间和应用前景。Nuclear factorκB(NF-κB)signaling pathway widely exists in mammalian cells,which can regulate the generation,development and activity of immune cells,and has been proved to affect the progress of many allergic and inflammatory diseases.Allergic conjunctivitis,as a hy⁃persensitive disease with allergic and inflammatory reactions,is also affected by NF-κB signal pathway regulation.According to the research progress of the role of NF-κB signaling pathway in allergic conjunctivitis,this paper found that NF-κB signaling pathway might affect allergic con⁃junctivitis by inflammatory response,keratoconjunctival tissue and vascular remodeling,immune response and so on.NF-κB signaling pathway's related targets and drugs had considerable re⁃search space and application prospects.

关 键 词：核因子ΚB 变态反应性结膜炎 免疫调节 炎症 研究进展 

分 类 号：R777.31[医药卫生—眼科]