结直肠癌CXCL12-CXCR4/CXCR7轴作用机制研究进展  

Research progress on the mechanism of CXCL12-CXCR4/CXCR7axis in colorectal cancer

作　　者：邓芳 王强[1] DENG Fang;WANG Qiang(Laboratory of Infection Immunity and Tumor Microenvironment,School of Medicine,Wuhan University of Science and Technology,Wuhan 435000,China)

机构地区：[1]武汉科技大学医学院感染免疫与肿瘤微环境研究室,湖北武汉435000

出　　处：《中华肿瘤防治杂志》2022年第23期1709-1714,共6页Chinese Journal of Cancer Prevention and Treatment

基　　金：国家自然科学基金(81573239)。

摘　　要：目的探讨趋化因子CXCL12及其受体与结直肠癌的关系,以总结最新研究进展。方法应用PubMed、Web of Science数据库和中国期刊全文数据库(CNKI)检索系统,以“结直肠癌、CXCL12、CXCR4、CXCR7、靶向治疗和趋化因子等”为中文关键词,以“colorectal cancer、CXCL12、CXCR4、CXCR7、targeted therapy、chemokines”等为英文关键词,检索2010-01-01-2022-03-31的相关文献,共检索到中文文献76篇,英文文献256篇。纳入标准:(1)结直肠癌发生时CXCL12、CXCR4和CXCR7表达水平变化;(2)CXCL12-CXCR4/CXCR7轴对结直肠癌发生发展的影响及作用机制;(3)靶向干预CXCL12-CXCR4/CXCR7轴对结直肠癌的影响及相关临床研究。排除标准:结直肠癌与非CXCL12/CXCR4或CXCL12/CXCR7信号轴。最终共纳入分析文献56篇,中文16篇,英文40篇。结果CXCL12及其受体在结直肠癌组织及常见转移部位表达显著升高,相关分子信号可通过CXCL12-CXCR4/CXCR7轴影响结直肠癌发生发展。CXCL12-CXCR4/CXCR7轴抑制剂能显著抑制结直肠癌细胞在体内外生长。结论CXCL12-CXCR4/CXCR7轴是未来治疗结直肠癌有效潜在靶点,有良好应用前景和价值,但需进一步探索和研究。Objective To investigate the relationship between Chemokine CXC ligand 12(CXCL12)and its receptor and colorectal cancer,and to summarize the latest research progress.Methods Using Pubmed,Web of Science database and Chinese Journal Full-text Database(CNKI)retrieval system,with"colorectal cancer,CXCL12,CXCR4,CXCR7,targeted therapy and chemokines"as the Chinese keywords,based on"colorectal cancer,CXCL12,CXCR4,CXCR7,targeted therapy,chemokines"and other English keywords,a total of 76Chinese literatures and 256English literatures were retrieved from January 2010to March 2022.Inclusion criteria:(1)Changes in the expression levels of CXCL12,CXCR4and CXCR7 during colorectal cancer;(2)The effect of CXCL12-CXCR4/CXCR7axis on the occurrence and development of colorectal cancer and its mechanism;(3)Effects of targeted intervention of CXCL12-CXCR4/CXCR7axis on colorectal cancer and related clinical studies.Exclusion criteria:colorectal cancer and non-CXCL12/CXCR4or CXCL12/CXCR7signaling axis.A total of 56articles were included in the analysis,including 16in Chinese and 40in English.Results The expression of CXCL12and its receptor is significantly increased in colorectal cancer tissues and common metastatic sites.Related molecular signals can affect the occurrence and development of colorectal cancer through CXCL12-CXCR4/CXCR7axis.CXCL12-CXCR4/CXCR7axis inhibitor can significantly inhibit the growth of colorectal cancer cells in vitro and in vivo.Conclusion CXCL12-CXCR4/CXCR7axis is an effective potential target for the treatment of colorectal cancer in the future,which has good application prospect and value,but it needs further exploration and research.

关 键 词：结直肠癌 趋化因子CXCL12 趋化因子受体4 趋化因子受体7 靶向治疗 

分 类 号：R735.3[医药卫生—肿瘤]