基于CiteSpace的m6A甲基化研究的文献可视化分析  

Visual Analysis of Literatures on m6A Methylation Based on CiteSpace

作　　者：黄金梅 朱素梅 覃淼 莫钧茹 覃仕娜 黎芳[1,2,3] 梁健钦 奉建芳[1,2,3] HUANG Jinmei;ZHU Sumei;QIN Miao;MO Junru;QIN Shina;LI Fang;LIANG Jianqin;FENG Jianfang(Guangxi University of Traditional Chinese Medicine,Nanning 530200,China;Guangxi Superior Proprietary Chinese Medicine and Ethnic Medicine Development Engineering Technology Research Center,Nanning 530200,China;Key Laboratory of Generic Technology Research and Development of Traditional Chinese Medicine Preparations,Guangxi University of Traditional Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西中医药大学,南宁530200 [2]广西优势中成药与民族药开发工程技术研究中心,南宁530200 [3]广西中医药大学中药制剂共性技术研发重点实验室,南宁530200

出　　处：《中国现代应用药学》2023年第1期57-67,共11页Chinese Journal of Modern Applied Pharmacy

基　　金：中国科学院科技服务网络计划(STS计划)区域重点项目(KFJ-STS-QYZD-2021-03-002);广西自然科学基金项目(2020GXNSFAA238035)。

摘　　要：目的分析近年m6A甲基化研究的发展状况、研究热点与前沿趋势。方法通过CNKI和Web of Science数据库检索2013—2021年m6A甲基化相关研究的文献,运用CiteSpace 5.8.R3软件对文献作者进行合作网络分析,对关键词进行共现、聚类和突现分析,绘制知识可视化图谱。结果共获得中文文献438篇、英文文献897篇,年度发文量呈快速增长趋势,高水平期刊主要集中在英文文献上,高产机构有南京医科大学、浙江大学、中山大学等高校。m6A甲基化研究高产作者主要有Chuan He、谷仕艳等,但尚未形成稳定的核心团队。关键词分析显示,m6A甲基化研究内容主要集中在检测技术、调控机制及靶向药物、预后风险模型等方面。结论m6A甲基化研究正处于高速发展时期,其测序技术、不同调控因子的分布状态与疾病发生发展之间的关联性等方向成为主要研究热点。未来,恶性肿瘤、肝细胞癌、胃癌、结直肠癌等疾病的m6A甲基化修饰相关性研究是主要方向。OBJECTIVE To detective the development status,hot spots and research trends of m6A methylation.METHODS CNKI and Web of Science core database were used to search the related literatures of m6A methylation from 2013to 2021.CiteSpace 5.8.R3 software was used to analyze the cooperative network of literature authors,co-occurrence,clustering and emergence of keywords,and to visualize the map of knowledge.RESULTS The 438 Chinese and 897 English literatures were selected,and the annual number of literatures showed a rapid growth trend.High level journals mainly focus on English literature.The analysis of the issuing institutions showed that Nanjing Medical University,Zhejiang University and Sun Yat-sen University were important scientific research institutions,which were the main research force.Chuan He and Gu Shiyan were the most prolific author in m6A methylation research field,but they had not yet formed a stable core research team.The keywords analysis of literature showed that the research related to detection technology,regulatory mechanisms and targeted drugs,prognostic risk model,and other related fields.CONCLUSION The research on m6A methylation is in a period of rapid development.It is a hot topic to the sequencing technology,the relationship between the distribution of different regulatory factors and the occurrence and development of diseases.In the future,it will be the development trend in malignant tumors,hepatocellular carcinoma,gastric cancer,colorectal cancer and other fields.

关 键 词：m6A CITESPACE 可视化分析 文献 

分 类 号：R914.2[医药卫生—药物化学]