营养风险筛查2002量表评分对鼻咽癌患者同步放化疗前远期生存状况的预测价值  

Predictive value of nutritional risk screening 2002 score before concurrent radiotherapy and chemotherapy for long-term survival of patients with nasopharyngeal carcinoma

作　　者：沙小娟 周树 黄晓萍 刘伟 程敏琼 Sha Xiaojuan;Zhou Shu;Huang Xiaoping;Liu Wei;Cheng Minqiong(Second Ward of Department of Radiotherapy,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;ICU of Department of Emergency,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院放疗科二病房,南京210029 [2]南京医科大学第一附属医院急诊ICU,南京210029

出　　处：《肿瘤综合治疗电子杂志》2023年第1期48-51,共4页Journal of Multidisciplinary Cancer Management(Electronic Version)

摘　　要：目的分析鼻咽癌患者同步放化疗前营养风险筛查2002(nutritional risk screening 2002,NRS 2002)量表评分对远期生存状况的预测价值。方法选取2017年1月至2019年5月南京医科大学第一附属医院收治的96例同步放化疗的鼻咽癌患者为研究对象,比较患者治疗前、治疗中期和治疗结束时的NRS 2002量表评分,分析治疗前NRS 2002量表评分与临床病理资料、术后生存状况的相关性,采用多因素Cox比例风险回归模型分析患者预后的预测因素。结果全部患者治疗前NRS2002量表评分<3分的比例显著高于治疗中期和治疗结束时的比例(均P<0.05),治疗中期NRS 2002量表评分<3分的比例显著高于治疗结束时的比例(P<0.05)。治疗前NRS 2002量表评分<3分的患者T_(3)+T_(4)、N_(2)+N_(3)、ⅣA期的占比显著低于评分≥3分者(P<0.05)。全部患者的中位生存时间为50.6个月,多因素Cox回归分析结果表明,治疗前NRS 2002量表评分≥3分、临床分期ⅣA期均为鼻咽癌患者同步放化疗前总生存时间的独立危险因素(均P<0.05)。结论NRS 2002量表对鼻咽癌患者同步放化疗前的远期生存状况有一定预测价值,治疗前NRS 2002量表评分≥3分、临床分期ⅣA期均为患者预后不良的独立危险因素。Objective To analyze the predictive value of nutritional risk screening 2002(NRS 2002)scale score before concurrent radiotherapy and chemotherapy for long-term survival of patients with nasopharyngeal carcinoma.Method Ninety-six patients with nasopharyngeal carcinoma treated with concurrent radiotherapy in the First Affiliated Hospital of Nanjing Medical University from January 2017 to May 2019 were enrolled for the research.The NRS 2002 scale score before,during and after treatment were compared,and the correlation between NRS 2002 scale score before treatment and clinicopathological data and postoperative survival was analyzed.Multivariate Cox proportional hazards regression model was performed to analyze the prognostic factors of patients.Result The proportion of NRS 2002 scale score<3 points before treatment of all patients was significantly higher than that in the middle and end of treatment(all P<0.05),and the proportion of NRS 2002 scale score<3 points in the middle of treatment was significantly higher than that at the end of treatment(P<0.05).The proportions of T_(3)+T_(4),N_(2)+N_(3)and ⅣA stage of patients with NRS 2002 scale score<3 points before treatment were significantly lower than those with scale score≥3 points(P<0.05).The median survival time of all patients was 50.6 months.Multivariate Cox regression analysis showed that NRS 2002 scale score≥3points before treatment andⅣA stage were the independent risk factors for overall survival time of nasopharyngeal carcinoma patients before concurrent radiotherapy and chemotherapy(all P<0.05).Conclusion The NRS 2002 scale score before concurrent radiotherapy and chemotherapy of nasopharyngeal carcinoma has a certain predictive value for long-term survival.Patients with NRS 2002 scale score≥3 points before treatment andⅣA stage are the independent risk factors for poor prognosis.

关 键 词：鼻咽癌 营养风险筛查表2002 同步放化疗 预后 

分 类 号：R739.63[医药卫生—肿瘤]