骨髓、脾脏FDG摄取水平与非小细胞肺癌临床病理特征  

FDG uptake level of bone marrow and spleen with clinicopathological features in non-small cell lung cancer patients

作　　者：卓尹杰 孙建男[2] 马焱鑫[2] 何志伟 ZHUO Yinjie;SUN Jiannan;MA Yanxin;HE Zhiwei(Graduate School,Daqing Campus of Harbin Medical University,Daqing 163319,China;Department of Imaging,Daqing Oilfield General Hospital,Daqing 163000,China)

机构地区：[1]哈尔滨医科大学大庆校区研究生院,黑龙江大庆163319 [2]大庆油田总医院影像科,黑龙江大庆163000

出　　处：《中国医学影像技术》2023年第2期216-221,共6页Chinese Journal of Medical Imaging Technology

摘　　要：目的观察^(18)F-FDG PET/CT所示骨髓及脾脏FDG摄取水平与非小细胞肺癌(NSCLC)患者临床病理特征的关系。方法纳入82例术前接受^(18)F-FDG PET/CT检查的NSCLC患者(NSCLC组)及41例非肿瘤患者(对照组),比较2组骨髓、脾脏FDG摄取水平差异,观察其与临床病理特征之间的关系。结果NSCLC组骨髓平均标准摄取值(SUV_(mean))、骨髓SUV_(mean)与肝脏SUV_(mean)比值(BLR),以及脾脏SUV_(mean)与肝脏SUV_(mean)比值(SLR)均高于对照组(P均<0.05)。男性患者、鳞癌、高TNM分期、肿瘤>3 cm及伴局部淋巴结转移者NSCLC原发灶的最大标准摄取值(SUV max)更高(P均<0.05);高TNM分期、肿瘤>3 cm及伴局部淋巴结转移患者骨髓SUV_(mean)及BLR更高(P均<0.05);高TNM分期及肿瘤>3 cm者SLR更高(P均<0.05);TNMⅢ期肿瘤患者脾脏SUV_(mean)高于TNMⅡ期(P<0.05)。结论NSCLC患者骨髓及脾脏高FDG摄取水平与反映不良预后的肿瘤临床病理特征相关。Objective To explore the relationships of FDG uptake level of bone marrow and spleen on ^(18)F-FDG PET/CT with clinicopathological features in patients with non-small cell lung cancer(NSCLC).Methods Totally 82 NSCLC patients who underwent preoperative ^(18)F-FDG PET/CT examination(NSCLC group)and 41 non-tumor patients(control group)were enrolled.The levels of FDG uptake in bone marrow and spleen were compared between groups,and the relationships of FDG uptake and clinicopathological features were analyzed.Results The mean standard uptake value(SUV_(mean))of bone marrow,bone marrow to liver uptake ratio(BLR),as well as spleen to liver uptake ratio(SLR)in NSCLC group were all higher than those in control group(all P<0.05).NSCLC patients who were male,with squamous cell carcinoma,high TNM stage,tumor size>3 cm and local lymph node metastases had higher primary focus maximum standard uptake value(SUV max)(all P<0.05).Patients with higher TNM stage,tumor size>3 cm and local lymph node metastases had higher bone marrow SUV_(mean) and BLR(all P<0.05),with higher TNM stage and tumor size>3 cm had higher SLR(both P<0.05).Splenic SUV_(mean) was only associated with TNM stage(P<0.05).Conclusion High FDG uptake of bone marrow and spleen in NSCLC patients were related to the clinicopathological features of tumor reflecting poor prognosis.

关 键 词：癌 非小细胞肺 单核巨噬细胞系统 骨髓 脾 体层摄影术 X线计算机 正电子发射断层显像 18F氟脱氧葡萄糖 

分 类 号：R734.2[医药卫生—肿瘤] R817.4[医药卫生—临床医学]