脑皮质层状坏死的研究进展  

Research Progress of Stratiform Necrosis of Cerebral Cortex

作　　者：王康 赵慧 高敏 张敬军 WANG Kang;ZHAO Hui;GAO Min;ZHANG Jing-jun(Department of Neurology,the Second Affiliated Hospital of Shandong First Medical University,Tai’an 271000,China)

机构地区：[1]山东第一医科大学第二附属医院神经内科,泰安271000

出　　处：《中国临床神经科学》2022年第6期689-695,共7页Chinese Journal of Clinical Neurosciences

摘　　要：脑皮质层状坏死在神经病学上表现为一个或者多个脑皮质出现坏死,多为局灶性或者弥漫性坏死,包括受累区域的神经元、神经胶质和血管的坏死,临床上常见于缺血缺氧性脑病、代谢性脑病、免疫性脑病、感染性脑病,等。脑皮质层状坏死主要存在“血管分布”和“异感选择”两种发病机制,后者主要包括:缺血缺氧性损害、氧化应激反应、兴奋性氨基酸毒性、血脑屏障破坏及神经炎症反应,等。Cortical layered necrosis is manifested in neurology as necrosis of one or more cerebral cortex,mostly focal or diffuse necrosis,including necrosis of neurons,glia and blood vessels in the affected area,which is common in clinical ischemic hypoxic encephalopathy,metabolic encephalopathy,immune encephalopathy,infectious encephalopathy,etc.There are two main mechanisms of cerebral cortical layered necrosis:vascular distribution and allopathic selection.The latter mainly includes ischemic hypoxia damage,oxidative stress response,excitatory amino acid toxicity,blood-brain barrier destruction and neuroinflammation.

关 键 词：脑皮质 层状坏死 血管分布 异感选择 

分 类 号：R743[医药卫生—神经病学与精神病学]