丙酮酸脱氢酶激酶-1在复发鼻咽癌组织中的表达及其与预后的关系  

High expression of pyruvate dehydrogenase kinase-1 in locally recurrent nasopharyngeal carcinoma predicts poor outcomes

作　　者：项光早 陈丽雅 曹辉[1] 林少雄[2] 林森 Xiang Guangzao;Chen Liya;Cao Hui;Lin Shaoxiong;Lin Sen(Second Affiliated Hospital of Shanghai University/Wenzhou Central Hospital,Zhejiang Wenzhou 325000,China;First Affiliated Hospital of Shantou University Medical College,Guangdong Shantou 515041,China;Third Affiliated Hospital of Wenzhou Medical University,Zhejiang Ruian 325200,China)

机构地区：[1]上海大学附属第二医院(温州市中心医院),浙江温州325000 [2]汕头大学医学院第一附属医院,广东汕头515041 [3]温州医科大学附属第三医院,浙江瑞安325200

出　　处：《中国医刊》2023年第3期294-297,共4页Chinese Journal of Medicine

基　　金：浙江省温州市科技计划(Y20210314)。

摘　　要：目的探讨丙酮酸脱氢酶激酶-1(pyruvate dehydrogenase kinase-1,PDK1)在局部复发鼻咽癌组织中的表达情况,并分析其与患者临床病理特征及预后的关系。方法选取2013年1月至2017年12月上海大学附属第二医院(温州市中心医院)和汕头大学医学院第一附属医院收治的92例局部复发鼻咽癌和45例初发鼻咽癌患者的临床标本,采用免疫组织化学法检测PDK1的表达情况,并分析其与患者临床病理特征的关系。采用Kaplan-Meier法进行生存分析,并采用Cox回归模型分析鼻咽癌局部复发的危险因素。结果初发鼻咽癌高表达PDK1蛋白的比例为31.11%,明显低于局部复发鼻咽癌(50.00%),差异有显著性(χ^(2)=4.38,P<0.05)。局部复发鼻咽癌组织中PDK1的表达情况与T分期、N分期、临床分期、远处转移、脑神经侵犯及颅底骨质破坏有关(P<0.05)。Kaplan-Meier生存分析表明,高表达PDK1的局部复发鼻咽癌患者5年生存率明显明显低于低表达者(P<0.05)。Cox回归模型多因素分析显示,高表达PDK1、远处转移、脑神经侵犯是鼻咽癌局部复发的独立危险因素(P<0.05)。结论高表达PDK1可能是鼻咽癌放疗后局部复发及预后不良的重要影响因素。Objective To investigate the expression of Pyruvate dehydrogenase kinase-1(PDK1)in the tissues of locally recurrent nasopharyngeal carcinoma(rNPC)and the association with the clinicopathological factors and prognosis.Method Immunohistochemistry was used to detect the expression of PDK1 in the tissues of primary and locally recurrent nasopharyngeal carcinoma.The relationship between PDK1 expression and clinicopathological features was analyzed using the Chi-square test.Kaplan-Meier method and Log-rank test were used for survival analysis.The prognostic factors were analyzed by Cox regression model.Result High PDK1 expression was showed in 50.00%of the patients with rNPC,significantly higher than 31.11%of primary nasopharyngeal carcinoma(χ^(2)=4.38,P<0.05).The high expression of PDK1 was associated with T stage,N grade,clinical stage,distant metastasis,cerebral nerve invasion and skull base bone destruction in patients with local recurrent nasopharyngeal carcinoma.Patients with high expression had a shorter time compared to the patients with low PDK1 expression.Multivariate analysis showed that high PDK1 expression was an independent predictor for patients with rNPC.Conclusion High expression of PDK1 may play an important role in the recurrence of rNPC.

关 键 词：鼻咽肿瘤 丙酮酸脱氢酶激酶-1 肿瘤复发 局部 

分 类 号：R739.6[医药卫生—肿瘤]