靶向肿瘤新生血管治疗的研究进展  

Progress on tumor therapy targeting tumor angiogenesis

作　　者：时晓蕾 程倩 王琳[1,2] SHI Xiaolei;CHENG Qian;WANG Lin(Department of Clinical Laboratory,Union Hospital Affiliated to Tongji Medical College,Huazhong University of Science&Technology,Wuhan,Hubei 430022,China;Tissue Engineering and Regenerative Medicine Research Center,Union Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院检验科,湖北武汉430022 [2]华中科技大学同济医学院附属协和医院组织工程与再生医学研究中心,湖北武汉430022

出　　处：《医药前沿》2022年第33期46-49,共4页Journal of Frontiers of Medicine

摘　　要：恶性肿瘤的生长依赖血管供能,大部分实体恶性肿瘤表现出高水平的肿瘤血管新生。肿瘤血管新生已被证明与肿瘤的增殖、侵袭、转移和治疗耐受密切相关。靶向肿瘤新生血管的治疗策略主要包括血管正常化和破坏/梗阻肿瘤血管,通过抑制肿瘤血管生成、破坏肿瘤血管和阻断肿瘤血流供应取得了显著的抗肿瘤效果。本文就靶向肿瘤新生血管治疗策略的研究进展进行综述,以期为该领域的深入研究提供一定帮助。The development of malignant tumors depends on blood vessels that supply adequate oxygen and nutrients.Most malignant solid tumors exhibit high levels of angiogenesis,which has been proved to be closely related to proliferation,invasion,metastasis,and treatment tolerance of tumor cells.Therapeutic strategies targeting tumor blood vessels include vascular normalization and vascular destruction/obstruction,showing great antitumor therapeutic efficacy by inhibiting tumor angiogenesis,destroying tumor vessels,and blocking tumor blood supply.This article reviews the research progress of targeted tumor neovascular therapy strategies,in order to provide some help for in-depth research in this field.

关 键 词：肿瘤血管新生 血管正常化 血管破坏/梗阻 肿瘤治疗 

分 类 号：R730[医药卫生—肿瘤]