可手术治疗的135例肺鳞癌患者预后的影响因素分析  

Prognostic factors of 135 patients with lung squamous cell carcinoma after surgery

作　　者：何宏博 刘雨轩 刘东雷[1] 吴恺[1] HE Hongbo;LIU Yuxuan;LIU Donglei;WU Kai(Department of Thoracic Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Medical College,Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院胸外科,河南郑州450052 [2]郑州大学医学院,河南郑州450052

出　　处：《肿瘤基础与临床》2022年第6期503-507,共5页journal of basic and clinical oncology

摘　　要：目的探讨可手术的肺鳞癌患者预后的相关因素。方法回顾性分析2016年1月至2018年8月郑州大学第一附属医院收治的135例术后肺鳞癌患者的临床资料,研究影响患者总生存期(OS)的相关因素。结果单因素分析显示,吸烟史、体重指数、手术方式、术后TNM分期、术后T分期、淋巴结转移、辅助化疗、辅助化疗周期与患者的OS相关。多因素分析发现,术后T分期、是否有淋巴结转移、体重指数、是否辅助化疗及辅助化疗周期是影响肺鳞癌患者OS的独立危险因素。结论肺鳞癌患者的预后较差,手术加辅助化疗的治疗方式可提高患者的预后,辅助化疗周期在4~6个周期最佳,术后T分期、淋巴结转移、体重指数都是肺鳞癌患者预后的重要指标。Objective To investigate the factors associated with the prognosis of patients with operable squamous lung cancer.Methods The clinical data of 135 patients with postoperative squamous lung cancer from January 2016 to August 2018 in the First Affiliated Hospital of Zhengzhou University were retrospectively analyzed.The factors associated with overall survival(OS)were investigated.Results The results of univariate analysis found that smoking history,body mass index,surgical procedure,postoperative TNM staging,postoperative T staging,lymph node metastasis,adjuvant chemotherapy,and adjuvant chemotherapy cycles were associated with OS of patients.The results of multifactorial analysis identified postoperative T staging,presence of lymph node metastasis,body mass index,adjuvant chemotherapy and the cycle of adjuvant chemotherapy were the independent risk factors for OS in patients with squamous lung cancer.Conclusion The prognosis of patients with squamous lung cancer is poor.Surgery plus adjuvant chemotherapy can improve the prognosis of patients,and the cycle of adjuvant chemotherapy is optimal in 4-6 cycles.postoperative T staging,lymph node metastasis,and body mass index are all important indicators for the prognosis of patients with squamous lung cancer.

关 键 词：肺鳞癌 手术治疗 生存 影响因素 

分 类 号：R734.2[医药卫生—肿瘤]