《WHO胸部肿瘤分类(第五版)》中胸膜恶性间皮瘤病理学诊断的进展  

Updates in the pathological diagnosis of Pleural Malignant Mesothelioma in the WHO classification of thoracic tumors (5th edition)

作　　者：朴正华 周新成 张幸 Piao Zhenghua;Zhou Xincheng;Zhang Xing(Ningbo Clinical Pathology Diagnosis Center,Department of Pathology,Ningbo315031,China;Hangzhou Medical College(Zhejiang Academy of Medical Sciences),School of Public Health,Hangzhou310013,China)

机构地区：[1]宁波市临床病理诊断中心,病理科,宁波315031 [2]杭州医学院(浙江省医学科学院),公共卫生学院,杭州310013

出　　处：《中华劳动卫生职业病杂志》2022年第12期956-960,共5页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：中日加强石棉相关癌症诊断能力项目;宁波市医学重点学科项目(2022-F30)。

摘　　要：《WHO胸部肿瘤分类(第五版)》在胸膜恶性间皮瘤部分主要有以下几点变化:1.确立了原位间皮瘤的概念及其诊断方法;2.新增了胸膜恶性间皮瘤的肿瘤分级,即根据上皮样间皮瘤的细胞异型性、核分裂活性及有无坏死分为低级别和高级别;3.把胸膜恶性间皮瘤的组织学特征分为组织结构、细胞及间质特征,细化了组织学特征与预后的相关性,同时对部分有争议的组织学形态进行了归类。本文主要围绕新版WHO分类病理学诊断相关的主要变化,对其临床意义进行了讨论。The WHO Classification of Thoracic Tumors(5th edition)mainly has the following changes in the chapter of pleural malignant mesothelioma.(1)The concept of mesothelioma in situ and its diagnostic method have been established for the first time;(2)The tumour grading of pleural malignant mesothelioma was added,it was divided into low grade and high grade according to the cellular atypia,mitotic activity and presence of necrosis.(3)The morphological features of pleural malignant mesothelioma was classified into architectural pattern,cellular and stromal features,the correlation between histological features and prognosis was refined,and some of the controversial cellular types have been reclassified.In this review,we introduced the changes of related pathologic diagnosis,in the WHO Classification of Thoracic Tumors(5^(th) edition)and discussed its clinical significance.

关 键 词：间皮瘤 胸膜恶性间皮瘤 第五版WHO分类 病理学诊断 原位间皮瘤 组织学分级 

分 类 号：R734.3[医药卫生—肿瘤]