Functional connectivity of the default mode network subsystems in patients with major depressive episodes with mixed features  

作　　者：Rui Liu Han Qi Lin Guan Hang Wu Jing Liu Xiaoya Li Juan Huang Ling Zhang Jingjing Zhou 

机构地区：[1]Beijing Key Laboratory of Mental Disorders,NationalClinical Research Center for Mental Disorders&National Center for Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing,China [2]CAS Key Laboratory of Behavioral Science,Institute of Psychology,Beijing,China [3]Department of Psychology,University of Chinese Academyof Sciences,Beijing,China

出　　处：《General Psychiatry》2022年第6期372-378,共7页综合精神医学（英文）

基　　金：This study was supported by the National Natural Science Foundation of China(81901368,82171526 and 82071531);the Capital's Funds for Health Improvement and Research(CFH2020-4-2125);the Beijing Municipal Administration of Hospitals Incubating Programme(PX2018064 and PX2020072);Beijing Hospitals Authority Youth Programme(QMS20211901).

摘　　要：Background The neuroimaging mechanism of major depressive episodes with mixed features(MMF)is not clear.Aims This study aimed to investigate the functional connectivity of the default mode network(DMN)subsystems among patients with MMF and patients with major depressive disorder without mixed features(MDD_(noMF)).Methods This study recruited 47 patients with MDD_(noMF)and 27 patients with MMF from Beijing Anding Hospital,Capital Medical University,between April 2021 and June 2022.Forty-five healthy controls(HCs)were recruited.All subjects underwent resting-state functional magnetic resonance imaging scanning and clinical assessments.Intranetwork and internetwork functional connectity were computed in the DMN core subsystem,dorsal medial prefrontal cortex(dMPFC)subsystem and medial temporal lobe(MTL)subsystem.Analysis of covariance method was performed to compare the intranetwork and internetwork functional connectivity in the DMN subsystems among the MDD_(noMP)MMF and HC groups.Results The functional connectivity within the DMN core(F=6.32,P_(FDR)=0.008)and MTL subsystems(F=4.45,P_(FDR)=0.021)showed significant differences among the MDD_(noMP) MMF and HC groups.Compared with the HC group,the patients with MDD_(noMF) and MMF had increased functional connectivity within the DMN MTL subsystem,and the patients with MMF also showed increased functional connectivity within the DMN core subsystem.Meanwhile,compared with the MDD_(noMP) the patients with MMF had increased functional connectivity within the DMN core subsystem(mean difference(MDD_(noMF)-MMF)=-0.08,SE=0.04,p=0.048).However,no significant differences were found within the DMN dMPFC subsystem and all the internetwork functional connectivity.Conclusions Our results indicated abnormal functional connectivity patterns of DMN subsystems in patients with MMF,findings potentially beneficial to deepen our understanding of MMF's neural basis.

关 键 词：PATIENTS MEDIAL CONNECTIVITY 

分 类 号：R749.4[医药卫生—神经病学与精神病学]