铁死亡调控机制及其在肠道疾病中的研究进展  

Regulatory mechanism and research progress of ferroptosis in intestinal diseases

作　　者：岑怡 王甜甜[1] 高兴杰 邹祖全 张进杰[1] CEN Yi;WANG Tiantian;GAO Xingjie;ZOU Zuquan;ZHANG Jingjie(Department of Food and Drug,Ningbo University,Ningbo 315000,China;Beilun District Center for Disease Control and Prevention,Ningbo 315000,China)

机构地区：[1]宁波大学食品与药学学院,宁波315000 [2]宁波市北仑区疾病预防控制中心,宁波315000

出　　处：《生命的化学》2022年第11期2071-2078,共8页Chemistry of Life

基　　金：水产品非宏量营养素的健康功效解析-国家重点研发计划“蓝色粮仓科技创新”重点专项(2018YFD0901105)。

摘　　要：肠道不仅是人体主要的消化器官,也是人体最大的免疫器官。近年来,全球肠道疾病发病率和死亡率不断上升,临床上常用的治疗方式虽然可以在一定程度上缓解症状,但在长期应用后几乎都存在疗效欠佳、不良反应多等缺点。铁死亡是一种调节性细胞死亡方式,其特征是铁依赖性脂质过氧化物和脂质活性氧的过度累积。随着对肠道疾病机制研究的不断深入,越来越多的证据表明,铁死亡参与了肠道疾病的发生和发展过程,在肠缺血再灌注损伤、炎症性肠病和结直肠癌中起着重要作用。本文综述了铁死亡的调控机制及其在肠缺血再灌注损伤、炎症性肠病和结直肠癌中的研究进展,为临床肠道疾病的诊治提供新的理论和策略。The intestine is not only the main digestive organ of the human body,but also the largest immune organ of the human body.In recent years,the incidence and mortality rates of intestinal diseases are increasing constantly all over the world.Although the commonly used clinical treatments can alleviate the disease to some extent,almost all of the treatments have disadvantages such as poor efficacy and many adverse reactions after long-term application.Ferroptosis is a form of regulatory cell death,which is mainly characterized by excessive accumulation of lipid peroxides and lipid reactive oxygen species.With the deepening of the research on the mechanism of intestinal diseases,more and more evidence has shown that ferroptosis plays a part in the occurrence and development of intestinal diseases,and plays an important role in intestinal ischemia reperfusion injury,inflammatory bowel disease and colorectal cancer.This paper summarizes the regulatory mechanism of ferroptosis and its research progress in intestinal ischemia reperfusion injury,inflammatory bowel disease and colorectal cancer,and provides new theories and strategies for clinical diagnosis and treatment of colorectal diseases.

关 键 词：铁死亡 肠缺血再灌注损伤 炎症性肠病 结直肠癌 调控机制 

分 类 号：R574[医药卫生—消化系统]