脑白质微结构改变与精神病临床高危  

Changes of microstructure of white matter and clinical high risk for psychosis

作　　者：陈真竹 薄奇静 赵蕾[1,2] 周媛 王传跃[1,2] Chen Zhenzhu;Bo Qijing;Zhao Lei;Zhou Yuan;Wang Chuanyue(The National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders and Beijing Institute for Brain Disorders Center of Schizophrenia,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China;Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100069,China;Key Laboratory of Behavioral Science,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China;Department of Psychology,University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]首都医科大学附属北京安定医院,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京市重点实验室,北京脑重大疾病研究院精神分裂症研究所,北京100088 [2]首都医科大学人脑保护高精尖创新中心,北京100069 [3]中国科学院心理研究所行为科学重点实验室,北京100101 [4]中国科学院大学心理学系,北京100049

出　　处：《中华行为医学与脑科学杂志》2022年第12期1137-1142,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金(81901355);北京市自然科学基金(7192081)。

摘　　要：目的对精神病临床高危人群的研究是近年来的研究热点,有助于疾病的早期识别及早期干预。脑白质纤维束是脑区间复杂信息传递功能的重要结构基础,既有文献表明,精神病临床高危个体存在白质微结构异常,且与其临床症状及功能相关。弥散张量磁共振成像是当前唯一非侵入性地研究脑白质微结构的技术。本文对利用弥散张量成像对精神病临床高危白质微结构异常的现有证据进行综述,旨在综合分析疾病早期潜在的神经生物标志及疾病发展中的病理演变特征。The research on clinical high-risk for psychosis is a hotspot in recent years,which is helpful to the early identification and early intervention of psychosis.White matter fibers are the important structural basis of complex information transmission function among brain regions.The existing literatures show that there are abnormal white matter microstructures in individuals at clinical high-risk for psychosis,which is related to their clinical symptoms and social function.Diffusion tensor imaging is the only non-invasive technique to study the microstructure of brain white matter.This paper reviews the existing evidences of microstructural abnormalities of white matter at clinical high-risk for psychosis by diffusion tensor imaging,in order to comprehensively analyze the potential neurobiomarkers in the early stage of the disease and the pathological evolution characteristics in the development of the disease.

关 键 词：精神病临床高危 超高危 弥散张量成像 白质微结构 白质完整性 

分 类 号：R749[医药卫生—神经病学与精神病学]