HPV感染高危女性宫颈癌认知程度影响因素及预防性HPV疫苗接种效果调查分析  

Analysis of the cognitive factors and the effect of preventive HPV vaccination in women with high risk of HPV infection

作　　者：白佳婕 Bai Jiajie(Department of Gynecology,Kaiyuan People's Hospital,Kaiyuan 661699,China)

机构地区：[1]开远市人民医院妇科,云南开远661699

出　　处：《实用妇科内分泌电子杂志》2022年第24期19-21,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的调查人乳头瘤病毒(HPV)感染高危女性人群对HPV疫苗接种预防宫颈癌的认知情况。方法选取行宫颈癌检验的妇女1246例作为研究样本,采用2代杂交捕获法筛选出HPV高危女性人群564例作为研究对象。其中自愿接种HPV疫苗的妇女296例作为观察组,拒绝接种HPV疫苗的妇女268例作为对照组。持续对HPV高危女性人群进行调查随访,比较两组宫颈癌认知情况、HPV疫苗接种预防宫颈癌效果。结果观察组HPV疫苗、HPV感染高危类型、宫颈癌与HPV之间的关系、HPV病毒传播途径、宫颈癌筛查方法和意义、宫颈癌检查频率、宫颈癌治愈几率、HPV阳性结果的意义认知评分均明显高于对照组,差异有统计学意义(P<0.05)。观察组HPV持续性感染、HPV16/18型机会感染、宫颈上皮内瘤变(CIN)Ⅰ~Ⅱ级分别为8例(2.70%)、2例(0.68%)、0,均低于对照组的58例(21.64%)、37例(13.81%)、13例(4.85%),差异有统计学意义(P<0.05)。结论HPV高危女性人群对宫颈癌认知程度越高越愿意接受HPV疫苗接种,可起到显著的预防宫颈癌效果。Objective To investigate the awareness of HPV vaccination against cervical cancer among women at high risk of human papillomavirus(HPV)infection.Methods A total of 1246 women who underwent cervical cancer examination were selected as the study samples,and 564 women at high risk of HPV were selected by two-generation hybridization capture method.Among them,296 women who volunteered for HPV vaccination served as the observation group and 268 women who refused HPV vaccination served as the control group.The HPV high-risk female population was continuously investigated and followed up to compare the cervical cancer cognition and the effect of HPV vaccination on cervical cancer prevention between the two groups.Results HPV vaccine,high-risk types of HPV infection,the relationship between cervical cancer and HPV,HPV virus transmission route,cervical cancer screening methods and significance,cervical cancer screening frequency,cervical cancer cure rate,HPV positive results of the observation group were significantly higher than the control group,the difference was statistically significant(P<0.05).In the observation group,there were 8 cases(2.70%)of HPV persistent infection,2 cases(0,68%)of HPV16/18 opportunistic infection,and 0 cases of cervical intraepithelial neoplasia(CINⅠ-Ⅱ),respectively,which were lower than those in the control group 58 cases(21.64%),37 cases(13.81%),13 cases(4.85%).The difference was statistically significant(P<0.05).Conclusion The higher the degree of recognition of cervical cancer,the more willing to accept HPV vaccination,which can play a significant role in the prevention of cervical cancer.

关 键 词：HPV高危女性人群 HPV疫苗接种 预防宫颈癌 认知情况 

分 类 号：R737.33[医药卫生—肿瘤] R186[医药卫生—临床医学]