卡培他滨联合化疗在晚期结直肠癌手术的治疗效果观察  

Effect Observation of Capecitabine Combined with Chemotherapy During Operation of Advanced Colorectal Cancer

作　　者：张环[1] 都敏[1] 唐德钧 ZHANG Huan;DU Min;TANG Dejun(Shenzhen Longgang District People's Hospital,Shenzhen,Guangdong,518172)

机构地区：[1]广东省深圳市龙岗区人民医院普外科,广东深圳518172

出　　处：《智慧健康》2022年第36期96-99,共4页Smart Healthcare

摘　　要：目的选取晚期结直肠癌患者为研究对象,采用联合化疗方案治疗后,加入卡培他滨维持治疗,观察其临床疗效。方法选取2018年10月-2020年10月本院收治的60例晚期结直肠癌患者,采用抽签法对其进行分组,其中对照组采用联合化疗方案进行治疗,观察组则在联合化疗治疗之后停药14d,行维持治疗(卡培他滨),经2个疗程治疗后比较两组间临床疗效、不良反应发生率与远期生存率。结果观察组总有效率73.3%高于对照组26.7%,数据差异显著(P<0.05)。观察组不良反应发生率与对照组比较,差异无显著性(P>0.05)。随访1年时,观察组生存率93.3%高于对照组70.0%,数据差异显著(P<0.05);随访2年时,观察组生存率83.3%高于对照组56.7%,数据差异显著(P<0.05)。结论临床上对晚期结直肠癌患者进行治疗时,在联合化疗后实施卡培他滨维持治疗可获得较为明显的临床疗效,远期生存率明显更高,可在临床上借鉴应用。Objective To observe clinical effect of capecitabine maintenance therapy for patients with advanced colorectal cancer after combined chemotherapy.Methods The paper chose 60 patients with advanced colorectal cancer in our hospital from October 2018 to October 2020,and divided them into groups by drawing lots.Control group was treated with combination chemotherapy,and observation group with maintenance therapy(capecitabine)14 days after combination chemotherapy.After two courses of treatment,clinical effect,adverse reaction rate and long-term survival rate between two groups was compared.Results Total effective rate of observation group was 73.3% higher than control group(26.7%),with significant difference(P<0.05).There was no significant difference in incidence of adverse reactions between observation group and control group(P>0.05).At 1 year follow-up,survival rate of observation group was 93.3% higher than control group(70.0%,P<0.05).During 2-year follow-up,the survival rate of observation group was 83.3% higher than control group(56.7%),with significant difference(P<0.05).Conclusion In clinical treatment of patients with advanced colorectal cancer,capecitabine maintenance therapy after combined chemotherapy can achieve more obvious clinical effect,with significantly higher long-term survival rate,which can be applied for clinical reference.

关 键 词：卡培他滨 化疗 手术 维持治疗 晚期结直肠癌患者 不良反应 

分 类 号：R735.34[医药卫生—肿瘤]