无催化剂条件下环状磺酰醛亚胺与肼的开环反应研究  

Study on the ring-opening of cyclic aldimines with hydrazines by catalyst-free

作　　者：刘兵[1] 李峰[2] LIU Bing;LI Feng(College of Food Engineering,Shangqiu Polytechnic,Shangqiu 476000,China;College of Chemistry and Chemical Engineering,Shangqiu Normal University,Shangqiu 476000,China)

机构地区：[1]商丘职业技术学院食品工程学院,河南商丘476000 [2]商丘师范学院化学化工学院,河南商丘476000

出　　处：《化学研究与应用》2023年第2期341-348,共8页Chemical Research and Application

基　　金：河南省高等学校重点科研项目(21A150044)资助;河南省高等学校重点科研项目(22A150051)资助。

摘　　要：本文开发了一种以环状磺酰醛亚胺与肼为原料,通过直接开环反应,以86~98%的产率合成了一系列邻羟基腙类衍生物。该方法具有条件温和、操作简便、官能团兼容性好等优点。此外,该反应策略可进行克级反应。通过控制实验研究,提出了可能的反应机理。A direct ring-opening of cyclic aldimines with hydrazines for the synthesis of o-hydroxy hydrazone derivatives in 86~98%yields was developed.This method featured mild conditions,simple operation,and good functional group tolerance.In addition,a gram-scale reaction was performed.According to the control experiment,a plausible mechanism for the reaction was proposed.

关 键 词：无催化剂 环状磺酰醛亚胺 肼 开环反应 邻羟基腙类衍生物 

分 类 号：O621.3[理学—有机化学]