大黄■虫丸治疗瘀血阻络型急性脑梗死临床研究  

Clinical Study on Dahuang Zhechong Pills for Acute Cerebral Infarction of Blood Stasis Obstructing the Collaterals Type

作　　者：李士科 LI Shike

机构地区：[1]河南中医药大学附属郑州中医骨伤病医院,河南郑州450016

出　　处：《新中医》2023年第1期72-75,共4页New Chinese Medicine

摘　　要：目的:观察大黄■虫丸结合西医治疗瘀血阻络型急性脑梗死的临床疗效及对患者血脂水平、炎症因子水平的影响。方法:将88例瘀血阻络型急性脑梗死患者随机分为治疗组与对照组各44例,对照组以常规西药治疗,治疗组在对照组基础上联合大黄■虫丸治疗。比较2组临床疗效,并比较2组治疗前后血脂水平、炎症因子水平及美国国立卫生研究院卒中量表(NIHSS)评分。结果:治疗前,2组NIHSS评分比较,差异无统计学意义(P>0.05)。治疗后,2组NIHSS评分均降低(P<0.05),且治疗组低于对照组(P<0.05)。治疗组总有效率为97.73%,高于对照组88.64%(P<0.05)。治疗前,2组血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平比较,差异无统计学意义(P>0.05)。治疗后,2组血清TC、TG、LDL-C水平均降低(P<0.05),HDL-C水平均升高(P<0.05),且治疗组血清TC、TG、LDL-C水平低于对照组(P<0.05),HDL-C水平高于对照组(P<0.05)。治疗前,2组血清C-反应蛋白(CRP)、白细胞介素-6 (IL-6)、白细胞介素-8 (IL-8)、肿瘤坏死因子-α (TNF-α)水平比较,差异无统计学意义(P>0.05)。治疗后,2组血清CRP、IL-6、IL-8、TNF-α水平均降低(P<0.05),且治疗组低于对照组(P<0.05)。结论:大黄■虫丸结合西医治疗瘀血阻络型急性脑梗死疗效较好,能有效减轻患者临床症状,提高患者治愈率,改善生化指标。Objective:To observe the clinical effect of Dahuang Zhechong Pills combined with western medicine for acute cerebral infarction of blood stasis obstructing the collaterals type and its effect on the levels of blood lipid and inflammatory factors in patients. Methods:A total of 88 cases of patients with acute cerebral infarction of blood stasis obstructing the collaterals type were randomly divided into the treatment group and the control group, with 44 cases in each group. The control group was treated with routine western medicine,and the treatment group was additionally treated with Dahuang Zhechong Pills based on the treatment of the control group. The clinical effects in the two groups were compared,and the levels of blood lipid,inflammatory factors and National Institutes of Health Stroke Scale(NIHSS) scores before and after treatment were compared between the two groups. Results: Before treatment, there was no significant difference being found in the comparison of NIHSS scores between the two groups(P>0.05).After treatment,NIHSS scores in the two groups were decreased(P<0.05),and the score in the treatment group was lower than that in the control group(P<0.05). The total effective rate was 97.73% in the treatment group, higher than that of 88.64% in the control group(P<0.05). Before treatment, there was no significant difference being found in the comparison of the levels of total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) in serum between the two groups(P>0.05). After treatment,the levels of TC,TG and LDL-C in serum in the two groups were decreased(P<0.05),and the levels of HDL-C were increased(P<0.05). The levels of TC,TG and LDL-C in serum in the treatment group were lower(P<0.05),and the level of HDL-C was higher than those in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparison of the levels of C-reactive protein(CRP), interleukin-6(IL-6), interleukin-8(IL-8) and tu

关 键 词：急性脑梗死 瘀血阻络型 大黄■虫丸 血脂 炎症因子 

分 类 号：R743.33[医药卫生—神经病学与精神病学]