益气养阴汤辅助化疗治疗晚期非小细胞肺癌癌因性疲乏临床研究  

Clinical Study on Yiqi Yangyin Decoction Assisting Chemotherapy for Cancer-Related Fatigue in Advanced Non-Small Cell Lung Cancer

作　　者：温从乐 顾长好 吕小雁 苏秀秀 WEN Congle;GU Changhao;LYU Xiaoyan;SU Xiuxiu

机构地区：[1]苍南县中医院内二科,浙江温州325800

出　　处：《新中医》2023年第1期146-150,共5页New Chinese Medicine

摘　　要：目的:观察益气养阴汤辅助化疗治疗晚期非小细胞肺癌癌因性疲乏的临床疗效。方法:选择80例晚期非小细胞肺癌患者为研究对象,按随机数字表法分为对照组和观察组各40例。对照组给予常规西药治疗,观察组在对照组基础上给予益气养阴汤治疗。比较2组临床疗效、癌因性疲乏、免疫功能及炎症因子水平。结果:观察组总缓解率为67.50%,高于对照组45.00%(P<0.05)。治疗后,2组癌因性疲乏各项评分较治疗前降低(P<0.05),且观察组各项评分低于对照组(P<0.05)。治疗后,2组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平较治疗前均降低,CD8^(+)较治疗前升高(P<0.05);但是观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组(P<0.05)。治疗后,2组白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、转化生长因子-β1(TGF-β1)、肿瘤坏死因子-α (TNF-α)水平较治疗前降低(P<0.05),且观察组IL-6、IL-1β、TGF-β1、TNF-α水平低于对照组(P<0.05)。结论:益气养阴汤辅助化疗治疗晚期非小细胞肺癌疗效较好,能有效缓解癌因性疲乏症状,降低化疗对机体免疫功能的损害,减轻炎症反应。Objective:To observe the clinical effect of Yiqi Yangyin Decoction assisting chemotherapy for cancer-related fatigue in advanced non-small cell lung cancer. Methods:A total of 80 cases of patients with advanced non-small cell lung cancer were selected as the study subjects and divided into the control group and the observation group according to the random number table method, with 40 cases in each group. The control group was treated with routine western medicine, and the observation group was additionally treated with Yiqi Yangyin Decoction based on the treatment of the control group. After treatment, the clinical effects, cancer-related fatigue, immune function and levels of inflammatory factors in the two groups were compared. Results:The total remission rate was 67.50% in the observation group,higher than that of 45.00% in the control group(P<0.05). After treatment,each score in cancerrelated fatigue in the two groups was decreased when compared with that before treatment(P<0.05),and each score in the observation group was lower than that in the control group(P<0.05). After treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups were decreased when compared with those before treatment,and the CD8^(+)level was increased(P<0.05);the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher,and the CD8^(+)level was lower than those in the control group(P<0.05).After treatment,the levels of interleukin-6(IL-6),interleukin-1β(IL-1β),transforming growth factor-β1(TGF-β1) and tumor necrosis factor-α(TNF-α) in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of IL-6,IL-1β,TGF-β1 and TNF-α in the observation group were lower than those in the control group(P<0.05). Conclusion:Yiqi Yangyin Decoction assisting chemotherapy for cancer-related fatigue has a good curative effect in treating advanced non-small cell lung cancer, which can effectively relieve symptoms of cancer-related fatigue, reduce the damage of chemotherapy

关 键 词：非小细胞肺癌 晚期 癌因性疲乏 益气养阴汤 化疗 免疫功能 炎症因子 

分 类 号：R734.2[医药卫生—肿瘤]