生物芯片技术在生物医学研究中的应用进展  

Application progress of biochip technology in biomedical research

作　　者：徐霁雪 张博文 魏鸾葶 梁辰昊 吴玉婷 赵艳[4] 李成[4] XU Jixue;ZHANG Bowen;WEI Luanting;LIANG Chenhao;WU Yuting;ZHAO Yan;LI Cheng(the First Clinical College,China Medical University,Shenyang,Liaoning,110000;the Queen′s University Belfast Joint College,China Medical University,Shenyang,Liaoning,110000;the Second Clinical Department,China Medical University,Shenyang,Liaoning,110000;Department of Immunology,China Medical University,Shenyang,Liaoning,110000)

机构地区：[1]中国医科大学第一临床学院,辽宁沈阳110000 [2]中国医科大学中英联合学院,辽宁沈阳110000 [3]中国医科大学临床二系,辽宁沈阳110000 [4]中国医科大学免疫学教研室,辽宁沈阳110000

出　　处：《实用临床医药杂志》2023年第1期126-130,共5页Journal of Clinical Medicine in Practice

基　　金：国家自然科学基金资助项目(82002163)。

摘　　要：生物芯片技术源于Southern印迹技术,是一项基于生物分子间特异性相互作用原理的高通量的微量分析技术。从单纯地将生物组分集成以降低成本、提高效率,到结合微刻技术及多种微流结构对实验步骤进行优化、集成,再到对组织、器官自然状态的模拟,生物芯片技术发展迅猛,且在医学生物研究领域展现出巨大的应用前景。本文简述生物芯片技术的概念、发展与分类,并对近年来不同类型生物芯片在生物医学研究中的最新应用进展进行综述。Biochip technology, which derived from Southern blotting technology, is a high-throughput micro-analysis technology based on the principle of specific interactions between biomolecules. From simply integrating biological components to reducing costs and improving efficiency, to optimizing and integrating experimental steps by combining microlithography technology and various microfluidic structures, then to simulating the natural state of tissues and organs, biochip technology is developing rapidly, and shows great application prospects in the field of medical biological research. This review briefly described the concept, development and classification of biochip technology, then systemarically enumerated the up-to-date application progress of different types of biochips in biomedical research.

关 键 词：生物芯片 生物医学 基因芯片 器官芯片 组织芯片 细胞芯片 

分 类 号：R-331[医药卫生] Q-337[生物学]