中药改善睡眠障碍动物学习记忆的物质基础及机制研究  

Research progress on pharmacodynamic material basis and mechanism of traditional Chinese medicine to improve learning and memory function in sleep-deprived animals

作　　者：王欢欢 马青 于爽[1] 王艳艳[1] 黄莉莉[1] WANG Huan-huan;MA Qing;YU Shuang;WANG Yan-yan;HUANG Li-li(Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学药学院,哈尔滨150040

出　　处：《中国药物依赖性杂志》2022年第5期365-368,374,共5页Chinese Journal of Drug Dependence

基　　金：国家自然科学基金项目(82003974);黑龙江省自然科学基金项目(LH2019H106,LH2020H098)。

摘　　要：失眠作为一种常见疾病,给人们的正常工作和生活带来严重影响,对学习记忆的影响尤为突出。目前,催眠镇静的药物以苯二氮艹卓类为主,虽起效快,但有较多不良反应且伴有认知障碍。大量研究表明,中药及复方不仅具有改善睡眠作用,而且具有益智作用。鉴于睡眠障碍问题日益广泛,对认知功能影响日益突出,本文通过阐述单味中药改善睡眠障碍后学习记忆的物质基础,将单味药及复方改善失眠后学习记忆的作用机制进行总结,以期为研究者开发改善睡眠及学习记忆功能的中药奠定基础,并为深入研究睡眠障碍对学习记忆的作用机制提供参考。As a common disorder, insomnia often brings serious effects on people′s work and normal daily life, especially on learning and memory. Although hypnotic sedative drugs like benzodiazepine act quickly, they can cause unavoidable side effects and accompany by cognitive impairment. Chinese medicine and Chinese herbal compound can improve sleep and intelligence. In view of the increasingly extensive problems of sleep deprivation and the increasingly prominent impact on cognitive function, this article reviews the material basis of single Chinese medicine and the mechanism of single Chinese medicine and Chinese herbal compound in improving learning and memory after sleep deprivation. This review provides a reference to develop Chinese medicine that can improve sleep, learning and memory function, and further clarify the mechanism of sleep deprivation on learning and memory for researchers.

关 键 词：中药 睡眠障碍 失眠 学习记忆 物质基础 

分 类 号：R749[医药卫生—神经病学与精神病学]