别嘌呤醇联合抗菌漱口水在预防白血病化疗所致口腔黏膜炎中的效果  

The Effects of Allopurinol Combined with Antibacterial Mouthwereh in Preventing Oral Mucositis Caused by Chemotherapy of Leukemia

作　　者：王秋影 王文阜 WANG Qiu-Ying;WANG Wen-Fu(Department of Stomatology,Liaojian Group Fuxin Mine General Hospital,Fuxin 122000,China)

机构地区：[1]辽健集团阜新矿总医院口腔科,辽宁阜新122000

出　　处：《中国药物经济学》2022年第12期47-50,共4页China Journal of Pharmaceutical Economics

摘　　要：目的 探讨别嘌呤醇联合抗菌漱口水在预防白血病化疗所致口腔黏膜炎中的效果。方法 选取2018年8月至2021年7月在辽健集团阜新矿总医院诊治的88例白血病患儿作为研究对象,随机分为对照组与联合组,各44例。所有患儿均给予化疗治疗,对照组给予口服别嘌呤醇治疗,联合组在对照组治疗基础上给予抗菌漱口水治疗,比较两组的治疗效果。结果 联合组治疗期间口腔黏膜炎发生率为2.3%(1/44),对照组口腔黏膜炎发生率为15.9%(7/44),差异有统计学意义(P<0.05)。联合组治疗第1个月、第2个月口腔疼痛评分均低于对照组(P<0.05)。联合组治疗第1个月、第2个月口腔菌落数均少于对照组(P<0.05)。联合组治疗有效率较对照组高(P<0.05)。结论 别嘌呤醇联合抗菌漱口水能有效预防白血病化疗所致口腔黏膜炎的发生,促进疼痛缓解,改善口腔微生物状况,提高患儿的综合治疗效果。Objective To explore the effects of allopurinol combined with antibacterial mouthwereh in preventing oral mucositis caused by chemotherapy of leukemia. Methods 88 cases of leukemia children diagnosed and treated in Liaojian Group Fuxin Mining General Hospital from August 2018 to July 2021 were selected as the research objects, and randomly divided into the control group and the combined group, 44 cases each. All children were treated with chemotherapy, the control group was treated with oral allopurinol, and the combined group was treated with antibacterial mouthwash on the basis of the control group. The therapeutic effects of the two groups were compared. Results During the treatment period, the incidence of oral mucositis in the combined group were 2.3%(1/44),the incidence of oral mucositis in the control group were 15.9%(7/44), the difference were significant(P<0.05). The oral pain scores in the 1st and s2nd months of treatment in the combined group were lower than those in the control group(P<0.05). The number of oral colonies in the 1st and 2nd months of treatment in the combined group were less than that in the control group(P<0.05). After treatment, the effective rate of combined group was higher than that of control group(P<0.05). Conclusion Allopurinol combined with antibacterial mouthwereh can effectively prevent the occurrence of oral mucositis caused by leukemia chemotherapy, promote pain relief, improve the oral microbial status,and improve the comprehensive treatment effect of children.

关 键 词：别嘌呤醇 抗菌漱口水 白血病 化疗 口腔黏膜炎 

分 类 号：R781.6[医药卫生—口腔医学] R988.2[医药卫生—临床医学]