MOG和AQP4抗体相关脱髓鞘疾病的研究进展  

Research Progress in Demyelinating Diseases Associated with MOG and AQP4 Antibodies

作　　者：程畅 王伟[1] 徐沙贝 CHENG Chang;WANG Wei;XU Sha-bei(Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院神经内科,武汉430030

出　　处：《神经损伤与功能重建》2023年第2期96-99,共4页Neural Injury and Functional Reconstruction

基　　金：国家重点研发计划(No.81070962)。

摘　　要：早期研究发现,髓鞘少突胶质细胞糖蛋白抗体(MOG-IgG)多存在于水通道蛋白4抗体(AQP4-IgG)阴性的视神经脊髓炎谱系疾病(NMOSD)患者中。随着研究的深入,与MOG抗体相关疾病的临床和影像学特点被发现与AQP4-IgG阳性的NMOSD有所重叠,又不尽相同。因此,本文总结目前国内外已发表的MOG-IgG阳性疾病和AQP4-IgG阳性NMOSD患者的研究,比较两者病理生理学、临床和影像学表现及预后特征,旨在提高对MOG和AQP4抗体阳性患者的鉴别。Early studies have found that myelin oligodendrocyte glycoprotein antibody(MOG-IgG) is mostly present in optic neuromyelitis spectrum disease(NMOSD) patients with aquaporin 4 antibody(AQP4-IgG)negative. With further study, the clinical and imaging features of MOG-antibody related diseases have been found to overlap with AQP4-IgG positive NMOSD, but not the same. This paper summarized the studies on patients with MoG-IgG positive diseases and AQP4-IgG positive NMOSD, and compared the pathophysiology,clinical and imaging manifestations and prognostic characteristics of the two, in order to improve the identification of patients with MOG and AQP4 antibody positive.

关 键 词：髓鞘少突胶质细胞糖蛋白抗体 水通道蛋白4抗体 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学] R744