浸润性乳腺癌患者组织P120ctn p53及CK5/6表达及意义分析  

Expressions and Significance of P120ctn, p53 and CK5/6 inTissues of Patients with Invasive Breast Carcinoma

作　　者：林伟强 袁惠玲 温润耀 叶建森 张爱玲 LIN Weiqiang;YUAN Huiling;WEN Runyao(Dongguan Hospital Affiliated to Southern Medical University/Dongguan People's Hospital,Guangdong Dongguan 523000,China)

机构地区：[1]南方医科大学附属东莞医院/东莞市人民医院乳腺科,广东东莞523000

出　　处：《河北医学》2023年第2期259-265,共7页Hebei Medicine

基　　金：国家自然科学基金委员会资助项目,(编号:81802625);广东省东莞市社会科技发展项目,(编号:2018507150011329)。

摘　　要：目的:探究浸润性乳腺癌(IBC)患者癌组织P120连环蛋白(catenin,P120ctn)、p53蛋白、细胞角蛋白5/6(CK5/6)表达及临床意义。方法:回顾性分析2018年10月至2021年10月120例IBC患者临床资料,采用免疫组织化学法检测癌组织、癌旁组织P120ctn、p53、CK5/6表达情况,并分析其与患者临床病理特征、术前新辅助化疗(NAC)疗效关系。结果:癌组织P120ctn、p53及CK5/6阳性表达率81.67%、75.83%、38.33%,显著高于癌旁组织的55.00%、15.00%、3.25%(P均<0.05);P120ctn表达与分子分型、淋巴结转移有关(P<0.05),p53与肿瘤直径、分子分型、组织学分级、淋巴结转移、临床分期有关(P<0.05),CK5/6与分子分型、组织学分级有关(P<0.05);Spearman秩相关分析显示,癌组织P120ctn、p53及CK5/6表达互呈正相关(r=0.384、0.406、0.581,P均<0.05);120例患者术前经2个周期NAC后,有效率为63.33%(76/120);单因素分析显示,肿瘤直径>2cm、组织学分级G3、淋巴结转移、P120ctn阳性表达、p53阳性表达、CK5/6阳性表达者有效率较低(P<0.05);多因素Logistic回归分析显示,淋巴结转移、P120ctn阳性表达、p53表达阳性是影响患者NAC疗效的危险因素(P<0.05)。结论:IBC患者癌组织P120ctn、p53、CK5/6表达明显升高,且与患者临床病理特征有关,其中P120ctn、p53阳性表达是患者术前NAC疗效的影响因素。Objective:To investigate the expressions and clinical significance of P120 catenin(P120ctn),p53 protein,and cytokeratin 5/6(CK5/6)in cancer tissues of patients with invasive breast carcinoma(IBC).Methods:The clinical data of 120 patients with IBC were retrospectively analyzed between October 2018 and October 2021.Immunohistochemistry was used to detect the expressions of CD31,p53,and CK5/6 in cancer tissues and adjacent tissues,and their relationship with the clinicopathological characteristics and preoperative neoadjuvant chemotherapy(NAC)efficacy were analyzed.Results:The positive expression rates of P120ctn,p53,and CK5/6 in cancer tissues were 81.67%,75.83%,and 38.33%,which were significantly higher than 55.00%,15.00%,and 3.25%in adjacent tissues(all P<0.05).P120ctn expression was correlated with molecular typing and lymph node metastasis(P<0.05),p53 was related to tumor diameter,molecular typing,histological grading,lymph node metastasis,and clinical staging(P<0.05),and CK5/6 was associated with molecular typing and histological grading(P<0.05).Spearman rank correlation analysis showed that the expressions of P120ctn,p53,and CK5/6 in cancer tissues were positively correlated with each other(r=0.384,0.406,0.581,allP<0.05).After 2 cycles of NAC for 120 patients before surgery,the effective rate was 63.33%(76/120).Univariate analysis showed that the effective rate was lower in patients with tumor diameter>2cm,histological grade G3,lymph node metastasis,P120ctn positive expression,p53 positive expression,and CK5/6 positive expression(P<0.05).Multivariate Logistic regression analysis revealed that lymph node metastasis,positive P120ctn expression,and positive p53 expression were risk factors affecting the efficacy of NAC in patients(P<0.05).Conclusion:The expressions of P120ctn,p53,and CK5/6 in cancer tissues of patients with IBC are significantly increased,and they are related to the clinicopathological characteristics of patients.The positive expressions of P120ctn and p53 are influencing factors for the efficac

关 键 词：浸润性乳腺癌 免疫组织化学 P120连环蛋白 P53蛋白 细胞角蛋白5/6 

分 类 号：R737.9[医药卫生—肿瘤]