联用西药对脑血栓NIHSS评分、血液流变学指标的影响  

Effect of Atorvastatin Combined With Clopidogrel on NIHSS Score and Hemorheology in Patients With Cerebral Thrombosis

作　　者：杨炜炜[1] 马昊杰 王伟伟[2] YANG Weiwei;MA Haojie;WANG Weiwei(Department of Rehabilitation,Rongcheng People's Hospital,Weihai Shandong 264300,China;Department of Emergency,Rongcheng People's Hospital,Weihai Shandong 264300,China)

机构地区：[1]荣成市人民医院康复科,山东威海264300 [2]荣成市人民医院急诊科,山东威海264300

出　　处：《中国卫生标准管理》2023年第2期158-161,共4页China Health Standard Management

摘　　要：目的探究阿托伐他汀与氯吡格雷联用治疗脑血栓对患者美国国立卫生研究院卒中量表(Nationalinstitute ofhealthstrokescale,NIHSS)评分以及血液流变学指标的影响。方法将2020年2月—2022年2月荣成市人民医院收治的120例脑血栓患者按照随机数字表法分为试验组(n=60)和参照组(n=60)。参照组采用阿托伐他汀联合阿司匹林治疗,试验组采用阿托伐他汀联合氯吡格雷进行治疗,比较两组患者的治疗后患者的NIHSS评分、血液流变学指标[红细胞压积(packed cellvolume,PCV)、全血低切黏度(wholeblood lowshearviscosity,WBLSV)、血浆黏度(plasma viscosity,PV)和全血高切黏度(wholebloodhigh shearviscosity,HBV)水平]以及治疗效果。结果治疗后两组的NIHSS评分均降低(P<0.05),且治疗后试验组的NIHSS评分低于参照组(P<0.05);治疗后试验组HBV、PCV、PV、WBLSV均低于参照组(均P<0.05);治疗3个月后试验组总有效率为96.67%,高于参照组的86.67%(P<0.05)。结论使用阿托伐他汀与氯吡格雷联用治疗脑血栓,可有效改善患者NIHSS评分以及血液流变学指标,减轻患者症状,提高治疗有效性,可在临床上借鉴应用。Objective To explore the effects of atorvastatin combined with clopidogrel in the treatment of cerebral thrombosis on the score of National institute of health stroke scale(NIHSS)and hemorheology indexes of patients.Methods A total of 120 patients with cerebral thrombosis admitted to Rongcheng People’s Hospital from February 2020 to February 2022 were randomly divided into experimental group(n=60)and reference group(n=60).The control group was treated with atorvastatin combined with aspirin,and the experimental group was treated with atorvastatin combined with clopidogrel.The NIHSS scores,hemorheology indexes[packed cell volume(PCV),whole blood low shear viscosity(WBLSV),plasma viscosity(PV),and whole blood high shear viscosity(HBV)levels]and therapeutic efficacy.Results After treatment,NIHSS score of both groups was decreased(P<0.05),and NIHSS score of experimental group was lower than that of reference group(P<0.05).After treatment,HBV,PCV,PV and WBLSV of experimental groups were lower than those of control group(all P<0.05);After3 months of treatment,the total effective rate of the experimental group was 96.67%higher than that of the control group(86.67%,P<0.05).Conclusion Atorvastatin combined with clopidogrel in the treatment of cerebral thrombosis can effectively improve the NIHSS score and hemorheology index of patients,reduce the symptoms of patients and improve the effectiveness of treatment,which can be used for reference in clinical practice.

关 键 词：阿托伐他汀 氯吡格雷 脑血栓 NIHSS评分 血液流变学 联合治疗 

分 类 号：R743[医药卫生—神经病学与精神病学]