伴与不伴躯体化症状青少年抑郁障碍病人白细胞介素水平研究  

Interleukin level in adolescent depressive disorders with and without somatic symptoms

作　　者：郜见亮[1,2,3] 莫大明 胡淑文 钟慧 GAO Jian-liang;MO Da-ming;HU Shu-wen;ZHONG Hui(Department of Child and Adolescent Psychology,Affiliated Psychological Hospital of Anhui Medical University,Hefei Anhui 230022;Department of Child and Adolescent Psychology,Hefei Fourth People′s Hospital,Hefei Anhui 230022;Department of Child and Adolescent Psychology,Anhui Mental Health Center,Hefei Anhui 230022,China)

机构地区：[1]安徽医科大学附属心理医院儿少心理科,安徽合肥230032 [2]安徽省合肥市第四人民医院儿少心理科,230032 [3]安徽省精神卫生中心儿少心理科,安徽合肥230032

出　　处：《蚌埠医学院学报》2023年第2期256-259,共4页Journal of Bengbu Medical College

基　　金：安徽省合肥市第四人民医院科研课题(HFSY2020ZD11)。

摘　　要：目的:检测青少年抑郁障碍病人血清白细胞介素(IL)水平,并分析其与躯体化症状的相关性。方法:选择2020年12月至2021年12月在合肥市第四人民医院治疗的13~18岁的青少年抑郁障碍病人93例,根据是否伴功能性躯体化症状(functional somatic symptoms,FSS),分为伴FSS组(40例)与不伴FSS组(53例)。同时选取32名正常青少年人群作为对照组。采用汉密尔顿抑郁量表(HAMD)、儿童躯体化量表(CSI)对疾病抑郁障碍现状进行评估。采用酶联免疫吸附试验法检测被试儿童血清IL-13及IL-12/23p40因子水平。结果:伴FSS青少年抑郁组IL-13因子水平显著高于不伴FSS组和对照组(P<0.05),不伴FSS组与对照组间差异无统计学意义(P>0.05);伴FSS组IL-12/23p40因子水平显著高于不伴FSS组(P<0.05),两者与对照组差异均无统计学意义(P>0.05)。IL-13水平与CSI总分及分因子分均呈正相关关系(r=0.360、0.286、0.366、0.310、0.336,P<0.01);IL-12/23p40水平与CSI总分及分因子分均呈正相关关系(r=0.333、0.360、0.275、0.280、0.313,P<0.01)。结论:伴躯体化症状的青少年抑郁病人的血清IL-13水平异常,且与躯体化症状呈正相关。Objective:To analyze the serum interleukin level in patients with adolescent depression disorders,and analyze its correlation with somatic symptoms.Methods:A total of 93 patients with adolescent depression disorders treated in the Hefei Fourth People′s Hospital from December 2020 to December 2021 were selected and divided into functional somatic symptoms(FSS)group(n=40)and non-FSS group(n=53)according to whether they were accompanied by FSS.At the same time,thirty-two volunteers were selected as the control group.The Hamilton depression rating scale(HAMD)and childhood somatization inventory(CSI)were used to evaluate the severity of disease.The enzyme-linked immunosorbent assay was applied to detect the levels of serum IL-13 and serum IL-12/23p40.Results:The level of IL-13 in FSS group was significantly higher than that of the non-FSS group and control group(P<0.05),and there was no statistically significant difference between the non-FSS group and control group(P>0.05).The level of IL-12/23p40 in the FSS group significantly higher than that in the non-FSS group(P<0.05),while both had no significant difference with control group(P>0.05).The level of IL-13 and IL-12/23p40 were positively correlated with CSI total score and its sub-factor scores(IL-13:r=0.360,0.286,0.366,0.310,0.336,P<0.01;IL-12/23p40:r=0.333,0.360,0.275,0.280,0.313,P<0.01).Conclusions:The level of serum IL-13 in adolescent depression patients with somatic symptoms is abnormal,and it has a positive correlation patients with somatic symptoms.

关 键 词：青少年抑郁 躯体化症状 白细胞介素-13 白细胞介素12/23p40 

分 类 号：R749.41[医药卫生—神经病学与精神病学]